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BMP4 — NFKB1
Text-mined interactions from Literome
Ahn et al., Clin Orthop Relat Res 2003
(Myositis Ossificans) :
To clarify the potential role of NF-kappaB in the pathophysiologic features of fibrodysplasia ossificans progressiva, the
role of
NF-kappaB in regulating
bone morphogenetic protein-4 signaling in patient derived lymphoblastoid cell lines was examined
Eliseev et al., Exp Cell Res 2006
(Bone Neoplasms...) :
Here, we show that in osteosarcoma Saos2 osteoblasts,
NFkappaB regulates the activity of the
BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells,
NFkappaB represses BMP/Smad signaling and BMP2 induced differentiation through Smad7
Sugimori et al., J Bone Miner Metab 2005
:
Thus,
BMP-2 induced NF-kappaB activation is mediated by PI3K/Akt signaling
Jo et al., Antioxid Redox Signal 2006
(Atherosclerosis...) :
The NADPH oxidase activation by
BMP4 then
leads to ROS production,
NF-kappaB activation, intercellular adhesion molecule 1 ( ICAM-1 ) expression, and subsequent increased monocyte adhesivity of endothelial cells
Tintut et al., J Investig Med 2006
(Atherosclerosis...) :
Binding of RANKL to its cognate receptor RANK induces
NF-kappaB signaling, which stimulates osteoclastic differentiation in preosteoclasts and
induces bone morphogenetic protein ( BMP-2 ) expression in chondrocytes
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
In this study, we investigated whether the nuclear transcription factor
NF-kappaB , implicated in PC metastasis, is
involved in transcriptional regulation and activation of BMP-2 or
BMP-4/Smad signaling in PC cells
Mohan et al., Invest Ophthalmol Vis Sci 1998
:
BMP2 and
BMP4 stimulated activation of
NF-kappaB ... Actinomycin D and SN50 peptide, but not SN50M control peptide, inhibited
NF-kappaB activation in
response to BMP2 or
BMP4