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GRAP2 — IL1A

Text-mined interactions from Literome

Varga et al., Int Immunol 1999 : While the extracellular signal regulated kinase ( ERK ) cascade was activated by both receptors, IL-1 preferentially stimulated Jun-N-terminal kinases (JNK) and p38 mitogen activated kinase or microtubule associated protein kinase ( MAPK )
Palsson et al., J Biol Chem 2000 : We have found that lethal toxin from Clostridium sordellii, which specifically inactivates the low molecular weight G proteins Ras, Rap, and Rac, inhibits the activation of p38 mitogen activated protein kinase ( MAPK ) by interleukin-1 (IL-1) in EL4.NOB-1 cells and primary fibroblasts
Surapisitchat et al., Proc Natl Acad Sci U S A 2001 (MAP Kinase Signaling System) : TNF-alpha or IL-1 alone activated ERK1/2, p38 , and JNK maximally at 15 min in HUVEC
Li et al., J Neurosci Res 2001 (MAP Kinase Signaling System) : Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) induced a time dependent activation of both p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB), with consequent increases in interleukin-1alpha (IL-1alpha) , tumor necrosis factor-alpha (TNF-alpha), and nitric oxide ( NO ) production
McDermott et al., J Biol Chem 2002 : Here we have further investigated the role of Ras and Rap in p38 MAPK activation by IL-1 ... Our study suggests that upon activation Ras becomes associated with IRAK, Traf-6, and TAK-1, possibly aiding the assembly of this multiprotein signaling complex required for p38 MAPK activation by IL-1
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : IL-1 rapidly induced the activation of extracellular-signal regulated kinase ( ERK ), protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Guo et al., J Biol Chem 2003 (Inflammation) : This strategy established the requirement for p38 activity for the lipopolysaccharide stimulated production of IL-10, IL-1beta , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9
Wang et al., Biol Pharm Bull 2005 (Melanoma) : However, IL-1Ra attenuated the enhanced phosphorylation level of p38 mitogen activated protein kinase ( p38 MAPK ) without affecting extracellular signal regulated protein kinase ( ERK ) inactivation induced by evodiamine
Kandere-Grzybowska et al., Br J Pharmacol 2006 : Quercetin 1-100 microM inhibited IL-1 induced IL-6 secretion, p38 and PKC-theta phosphorylation in a dose dependent manner
Hsu et al., J Agric Food Chem 2006 : In essence, we found that c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase ( p38 ), but not extracellular signal regulated kinase ( ERK ), play an important role in the regulation of IL-1 gene expression in RASP stimulated J774A.1 cells
Fan et al., Cell Signal 2011 : Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type, K158R mutant, or K209R mutant TAK1 reveals that TAK1 Lys-158 but not Lys-209 is required for IL-1ß induced IKK, p38 and JNK activation
Eda et al., Rheumatol Int 2011 (MAP Kinase Signaling System) : IL-1ß- and TNF-a mediated induction of M-CSF mRNA was not affected by p38 , JNK, and MEK-1/2 inhibitors
Eijkelkamp et al., Mol Med 2012 (Hyperalgesia...) : In vitro, IL-1ß induced p38 phosphorylation in GRK6?/? dorsal root ganglion ( DRG ) neurons was increased compared with WT neurons
Gao et al., PloS one 2013 : We further observed that rotenone induced caspase-1 activation and mature IL-1ß release, both of which are strictly dependent on p38 mitogen activated protein kinase ( MAPK )
Larsen et al., J Biol Chem 1998 : By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay, IL-1beta was shown to activate extracellular signal regulated kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( p38 ) in islets and rat insulinoma cells