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CRH — NFKB1
Text-mined interactions from Literome
Karalis et al., J Biol Chem 2004
:
In a recent study in the pituitary corticotroph cell line AtT20, oxidative stress stimulated the activity of nuclear transcription factor B ( NF-kappaB ), whereas
corticotropin releasing hormone (CRH) inhibited both the constitutive and the oxidative stress induced
NF-kappaB DNA binding activity ... In agreement with a previous report,
CRH inhibited the constitutive
NF-kappaB DNA binding activity in AtT20 cells, as shown by electrophoretic mobility-shift assay, as soon as within 15 min of treatment ... Our findings provide evidence that the
regulation of corticotroph
NF-kappaB activity by
CRH is related to the activation of the pituitary POMC gene and, thus, may play an important role in stress response
Zbytek et al., J Endocrinol 2004
(Translocation, Genetic) :
CRH dependent stimulation of
NF-kappaB activity is consistent with accumulated data about role of this neuropeptide in the regulation of local epidermal homeostasis
Zbytek et al., Peptides 2006
:
CRH inhibits NF-kappa B signaling in human melanocytes ...
CRH inhibits NF-kappaB activity in human immortalized epidermal ( PIG1 ) melanocytes
Wu et al., Atherosclerosis 2009
(Atherosclerosis...) :
Meanwhile, both the enhanced expression of VCAM-1 and increased activation of
NF-kappaB induced by
CRH in aortas of LDLr-/- mice were also largely suppressed by NBI27914, whereas these inhibitory effects were not observed in anti-Svg-30 group ... The enhanced VCAM-1 expression which probably resulted from increased activation of
NF-kappaB induced by
CRH , may be one of the important molecular mechanisms by which CRH accelerates atherosclerosis
Zhang et al., Br J Pharmacol 2009
:
These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via
CRF ( 2 ) receptors and the
activation of p38MAPK and
NF-kappaB
Zocco et al., Mol Immunol 2010
(Calcium Signaling) :
Histamine modulation of peripheral
CRH receptor type 1alpha expression is
dependent on Ca ( 2+ ) signalling and
NF-kappaB/p65 transcriptional activity