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LTB — NFKB1
Text-mined interactions from Literome
Müller et al., J Biol Chem 2003
:
Lymphotoxin beta receptor induces sequential activation of distinct
NF-kappa B factors via separate signaling pathways ...
Lymphotoxin beta receptor (LTbetaR) induced activation of
NF-kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or second pathway
Huang et al., Arterioscler Thromb Vasc Biol 2004
:
Furthermore,
LTB4 increased NF-[kappa]B DNA binding activity, which was blocked by CP-105,696
Shim et al., Genes Dev 2005
:
However, TAK1 is not required for
NF-kappaB activation through the alternative pathway following
LT-beta signaling
Kanda et al., Clin Exp Allergy 2007
:
LTB ( 4 ) alone did not enhance CCL27 production and modestly
enhanced NF-kappaB activity in human keratinocytes ... However,
LTB ( 4 ) potently
enhanced TNF-alpha induced CCL27 secretion and mRNA expression and
NF-kappaB activity
Dhawan et al., J Biol Chem 2008
(Melanoma...) :
These results indicate that the
LTbeta-R constitutively
induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells
Vallabhapurapu et al., Eur J Immunol 2008
:
NF-kappaB also
regulates TCR induced expression of LT-alpha and
LT-beta within NKT cells
Razani et al., Science signaling 2010
:
Here, we describe a mechanism of negative feedback control of noncanonical NF-kappaB signaling that attenuated the stabilization of
NF-kappaB inducing kinase (NIK) , the central regulatory kinase of the noncanonical pathway,
induced by B cell activating factor receptor ( BAFF-R ) and
lymphotoxin beta receptor (LTbetaR)
Mackay et al., J Biol Chem 1996
:
Here, we show that engagement of
LTbeta-R with a soluble form of LTalpha1beta2 or with a specific anti-LTbeta-R agonistic monoclonal antibody CBE11 quickly
induces activation of
NFkappaB in HT-29 and WiDr human adenocarcinomas ...
LTbeta-R triggering
activates NFkappaB and induces proliferation in WI-38 human lung fibroblasts ... Thus, like several other members of the TNF receptor family, the
LTbeta-R can
activate NFkappaB following receptor ligation in some but not all LTbeta-R positive cells
Ware et al., J Cell Biochem 1996
:
The TRAF family of Zn RING/finger proteins bind to TNFR80 ; CD40 and
LT beta R are
involved in induction
NF kappa B and cell survival
VanArsdale et al., Proc Natl Acad Sci U S A 1997
(Adenocarcinoma) :
The binding of heterotrimeric lymphotoxin, LT alpha1 beta2, to the
LTbeta receptor (LTbeta R) , a member of the tumor necrosis factor receptor (TNFR) superfamily,
induces nuclear factor kappaB (NF-kappaB) activation and cell death in HT29 adenocarcinoma cells