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Dong et al., Cancer Res 2010
:
In keratinocytes, MSH bound to the melanocyte melanocortin receptor type 1 and activated adenylate cyclase activity, which in turn activated Xeroderma pigmentosum group A (XPA) binding protein 1 and induced nuclear translocation of XPA, a critical factor controlling nucleotide excision repair signaling pathways
Niles et al., J Supramol Struct 1979
(Melanoma...) :
In both cell types adenylate cyclase activity was markedly stimulated by MSH Siegrist et al., J Recept Res 1993
(Melanoma...) :
We have examined the mechanism of homologous regulation of MSH receptor binding and receptor mediated adenylate cyclase activation in three human and two mouse melanoma cell lines ... The increase in alpha-MSH binding was independent of adenylate cyclase activation and protein synthesis and appeared to be caused by recruitment of spare receptors