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IRAK2 — TLR5
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IRAK2
→
TLR5
(reaction)
Kollewe et al., J Biol Chem 2004, Rao et al., Mol Cell Biol 2005, Gottipati et al., Cell Signal 2008, Kawagoe et al., Nat Immunol 2008, Wan et al., J Biol Chem 2009
-
Reactome Reaction:
IRAK2
→
TLR5
(indirect_complex)
Rao et al., Mol Cell Biol 2005, Gottipati et al., Cell Signal 2008, Kawagoe et al., Nat Immunol 2008, Wan et al., J Biol Chem 2009
Text-mined interactions from Literome
Kobayashi et al., Cell 2002
(Salmonella Infections) :
Thus,
IRAK-M regulates TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003
:
PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting
TLR induced IRAK activation
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88,
IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Keating et al., J Biol Chem 2007
:
Thus we propose that
IRAK-2 plays a more central role than IRAK-1 in
TLR signaling to NFkappaB
Kawagoe et al., Nat Immunol 2008
:
Thus, IRAK2 is critical in late-phase
TLR responses , and IRAK1 and
IRAK2 are essential for the initial responses to TLR stimulation
Flannery et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Thus IRAK-2 in mice and humans may function differently, and therefore we analyzed the
role of
IRAK-2 in
TLR responses in primary human cells ... Collectively, these data demonstrate for the first time an essential
role for
IRAK-2 in primary human cells for both transcriptional and post-transcriptional
TLR responses