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CASP12 — TAT

Text-mined interactions from Literome

Cantaluppi et al., AIDS Res Hum Retroviruses 2001 (Sarcoma, Kaposi) : In contrast, Tat upregulated Bcl-X ( L ) expression and induced a relevant decrease in caspase-3 activity in vincristine treated KS cells
Park et al., J Immunol 2001 : HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation
Singh et al., J Neurovirol 2004 (Nerve Degeneration) : Both HIV-1 Tat and gp120 significantly increased caspase-3 activation in a concentration dependent manner in striatal neurons at 4 h following continuous exposure in vitro ... Tat ( 1-72 ) and gp120 caused significant neuronal losses at 48 h and/or 72 h. Tat ( 1-72 ) increased cytochrome c release, and caspase-3 and endo G activation at 4 h, 24 h, and/or 72 h
Klein et al., Biochem Biophys Res Commun 2004 : Spontaneous caspase activation in human islets and cytotoxicity caused by IL-1beta were significantly reduced in the presence of TAT-Bcl-XL and TAT-BH4
Fiala et al., Cardiovasc Toxicol 2004 (Cardiomyopathies...) : HIV-1, gp120, or Tat induced Erk 1/2 phosphorylation, activation of caspase-3 , and apoptosis of NRVMs and CAECs ; all of these were inhibited by a MAPK/ERK-kinase (MEK) inhibitor U0126
Singh et al., Neuroscience 2005 (Nerve Degeneration) : Both Tat and gp120 caused significant increases in p38 and c-jun-N-terminal kinase mitogen activated protein kinase phosphorylation, caspase-3 activity, neurite losses and cell death in striatal neurons ... Tat induced increases in caspase-3 activity were significantly attenuated by an inhibitor of c-jun-N-terminal kinase ( anthra [ 1,9-cd ] pyrazol-6 ( 2H ) -one ), but not by an inhibitor of p38 ( [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsul-finylphenyl ) -5- ( 4-pyridyl ) 1 H-imidazole ] ), mitogen activated protein kinase
Kilic et al., CNS Drug Rev 2005 (Brain Ischemia...) : When administered after optic nerve transection and focal cerebral ischemia, TAT-GDNF protected retinal ganglion cells and brain neurons from cell death, elevated tissue Bcl-XL levels and attenuated the activity of the executioner caspase-3
Yan et al., Oncogene 2006 (Melanoma...) : The TAT-Surv proteins were purified by sequential affinity and ion-exchange chromatography, and at 30 nM concentration demonstrated rapid entry into cells at 30 min. Whereas TAT-Surv-WT had minimal effect on YUSAC2 or WM793 melanoma cells, TAT-Surv-T34A induced cell detachment, DNA fragmentation, caspase-3 activation and mitochondrial release of apoptosis inducing factor at low microM concentrations
Buch et al., Neuroscience 2007 : Although morphine or Tat caused increases in caspase-3 activity at 4 h, this was not accompanied with increased cleaved caspase-3 immunoreactive or ethidium monoazide positive dying cells at 24 h
Michod et al., Mol Cancer Res 2007 (MAP Kinase Signaling System...) : TAT-RasGAP ( 317-326 ) did not affect PUMA levels, however, but increased genotoxin induced mitochondrial depolarization and caspase-3 activation
Pain et al., Toxicology 2008 : A cell-permeable peptide inhibitor TAT-JBD reduces the MPP+ induced caspase-9 activation but does not prevent the dopaminergic degeneration in substantia nigra of rats
Adams et al., Synapse 2010 : In addition, select components of apoptotic pathway signaling appear more sensitive to estrogen receptor ( ER ) activation, as the addition of ER antagonist ICI 182780 reversed estrogen downregulation of Bax and caspase 3, while estrogen effects on Tat induced Bcl-2 and caspase 9 expression were maintained
Buccigrossi et al., PloS one 2011 : Tat also induced cytochrome c release from mitochondria to cytosol, and caspase-3 activation
Kruman et al., Exp Neurol 1998 (AIDS Dementia Complex) : Tat induced caspase activation, and the caspase inhibitor zVAD-fmk prevented Tat induced neuronal death