Gene interactions and pathways from curated databases and text-mining

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ESR1 — PPP5C

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Traupe et al., Hypertension 2007 : Within 5 minutes, selective ERalpha activation by PPT , but not 17beta-estradiol or the ERbeta agonist DPN, caused rapid, NO-dependent, and endothelium dependent relaxation ( 49+/-5 % ; P < 0.001 versus ethanol )
Lahm et al., Am J Physiol Regul Integr Comp Physiol 2008 (Anoxia) : Selective ER-alpha activation ( PPT , 5 x 10 ( -5 ) M ) rapidly ( < 20 min ) decreased phenylephrine induced vasoconstriction
Chen et al., J Bone Miner Res 2009 : ERalpha agonist propylpyrazoletriol (PPT) and ERbeta agonist diarylpropionitrile ( DPN ) attenuated EtOH induced ERalpha and ERbeta gene overexpression, respectively
Thammacharoen et al., Brain Res 2009 : The anomalously rapid eating-inhibitory effect of PPT suggests that PPT 's neuropharmacological effect differs from estradiol 's, perhaps because PPT differentially activates membrane versus nuclear ER-alpha or because PPT activates non-ER-alpha membrane estrogen receptors in addition to ER-alpha