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Lupien et al., Mol Endocrinol 2007
:
Here, we show that the full antiestrogen ICI182,780 and, to a lesser extent, the selective ER modulator raloxifene (Ral) , induce accumulation of exogenous ERalpha in a poorly soluble fraction in transiently transfected HepG2 or stably transfected MDA-MB231 cells and of endogenous receptor in MCF7 cells
Dixon et al., Am J Nephrol 2007
(Diabetic Nephropathies...) :
RAL activates estrogen receptors and estrogen-receptor mediated cellular events without the side effects of E2