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INS — MMP12

Text-mined interactions from Literome

Jormsjö et al., Circ Res 2000 (Coronary Disease...) : Phorbol 12-myristate 13-acetate ( PMA ) and insulin , 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele ... Furthermore, Western blot analysis demonstrated that insulin increased MMP-12 protein production
Boden et al., Diabetes 2008 (Hyperinsulinism) : FFA augmented the insulin mediated increases in MMP-2 ( from approximately 6- to approximately 11-fold ), MMP-9 ( from approximately 3- to approximately 23-fold ), MT1-MMP ( from approximately 8- to approximately 20-fold ), MMP-2 gelatinolytic activity ( from 2- to 3-fold ), and JNK and p38 mitogen activated protein kinase ( MAPK ) activities but decreased insulin mediated activation of PI3K and ERK1/2