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CRKL — XRCC6

Text-mined interactions from Literome

Grumbach et al., Br J Haematol 2001 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In addition to its interaction with Stat5, CrkL interacts with C3G in KT-1 cells and such an interaction regulates the downstream activation of the small GTPase Rap1 , which also mediates inhibition of cell proliferation
Posern et al., Oncogene 2000 (MAP Kinase Signaling System) : We conclude that cellular Crk/CRKL complexes, recruited to upstream signaling components, contribute to basal and bombesin induced Rap1 activity, which is independent from the Ras-Raf-Erk pathway under these circumstances
Segovis et al., J Immunol 2009 : Furthermore, our data indicate that the small Ras family GTPase Rap1 is activated downstream of NKG2D engagement in a PI3K- and CrkL dependent manner and is required for conjugate formation, MTOC ( microtubule organizing center ) polarization, and NKG2D dependent cellular cytotoxicity