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DOK1 — MAPK4
Text-mined interactions from Literome
Jones et al., Curr Biol 1999
(MAP Kinase Signaling System) :
Interestingly, we have found that
Dok-R could
attenuate EGF stimulated
mitogen activated protein ( MAP ) kinase activation independently of its association with rasGAP
Di Cristofano et al., J Exp Med 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
p62(dok) , a negative
regulator of Ras and mitogen activated protein kinase (
MAPK ) activity, opposes leukemogenesis by p210 ( bcr-abl )
Zhao et al., Mol Cell Biol 2006
:
On the other hand,
Dok-1 negatively
regulates PDGF induced
MAPK activation by acting on Ras-GAP and at least one other Dok-1 interacting protein