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DNTT — FASLG
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Genovese et al., Neuroscience 2007
(Disease Models, Animal...) :
Treatment of the mice with etanercept ( 1.25 mg/kg ) and DEX ( 0.025 mg/kg ) when administered as a combination therapy but not as a single treatment significantly reduced the degree of ( 1 ) spinal cord inflammation and tissue injury ( histological score ), ( 2 ) infiltration of neutrophils ( MPO evaluation ), ( 3 ) inducible nitric oxide synthase, nitrotyrosine, and cytokines expression ( tumor necrosis factor-alpha and interleukin-1 beta ), ( 4 ) and apoptosis (
Terminal deoxynucleotidyltransferase mediated UTP end labeling staining,
Fas-ligand expression and Bax and Bcl-2 expression )
Paterniti et al., J Neurochem 2010
(Disease Models, Animal...) :
Treatment with T0901317, 1 and 6 h after the SCI, significantly decreased ( i ) the degree of spinal cord inflammation and tissue injury ( histological score ) ; ( ii ) neutrophil infiltration ( myeloperoxidase activity ) ; ( iii ) inducible nitric oxide synthase expression ; ( iv ) nitrotyrosine, lipid peroxidation, and poly-ADP-ribose formation ; ( v ) pro-inflammatory cytokines expression ; ( vi ) nuclear factor-kappa B activation ; and ( vii ) apoptosis (
terminal deoxynucleotidyltransferase mediated UTP end labeling staining,
FAS ligand , Bax, and Bcl-2 expression )