Gene interactions and pathways from curated databases and text-mining

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CCL19 — CCR7

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kohout et al., J Biol Chem 2004 : However, only activation by CCL19 , not CCL21, promotes robust desensitization of endogenous CCR7 in the human T cell lymphoma cell line H9
Zidar et al., Proc Natl Acad Sci U S A 2009 : CCL19 leads to robust CCR7 phosphorylation and beta-arrestin2 recruitment catalyzed by both GRK3 and GRK6 whereas CCL21 activates GRK6 alone
Muthuswamy et al., Blood 2010 (Melanoma) : PGE ( 2 ) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
Mburu et al., Carcinogenesis 2011 (Carcinoma, Squamous Cell...) : Indeed, treatment of non-metastatic SCCHN cells with hBD3 induced surface CCR7 expression and migration toward its ligand, CCL19