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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to CD40LG
CD40LG — TRAF1
Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus :
TRAF1
→
CD40LG
(increases)
Zirlik et al., Arterioscler Thromb Vasc Biol 2007 *
Ligation of CD40 enhanced the total protein expression of TRAF-1, -2, -3, and -6, but not TRAF-5 in ECs.
NCI Pathway Database CD40/CD40L signaling :
CD40/CD40L (trimer)/TTRAP complex (CD40LG-CD40-TDP2)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, inhibits)
Pullen et al., J Biol Chem 1999 , Pype et al., J Biol Chem 2000 , Hostager et al., J Biol Chem 2003 , Xie et al., J Immunol 2006
mutant phenotype, assay
NCI Pathway Database CD40/CD40L signaling :
TRAF2/CBL-b complex (TRAF2-CBLB)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(proteasomal ubiquitin-dependent protein catabolic process, collaborate)
Brown et al., J Exp Med 2001 , Brown et al., J Biol Chem 2002 , Arron et al., J Exp Med 2002 , Qiao et al., J Immunol 2007
mutant phenotype, assay
NCI Pathway Database CD40/CD40L signaling :
TRAF1 (TRAF1)
→
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
(modification, collaborate)
Rothe et al., Science 1995
physical interaction
NCI Pathway Database CD40/CD40L signaling :
TRAF1 (TRAF1)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, collaborate)
Rothe et al., Science 1995
physical interaction
NCI Pathway Database CD40/CD40L signaling :
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, collaborate)
Rothe et al., Science 1995
physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *