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CASP2 — CDK5

Text-mined interactions from Literome

Sandal et al., J Biol Chem 2002 (Leukemia, Promyelocytic, Acute) : The inhibition of CDK5 prevented the cleavage of pro-caspase-3 in cAMP treated cells
Weishaupt et al., Mol Cell Neurosci 2003 (Brain Ischemia...) : We find that blocking CDK5 activity, but not caspase inhibition , protects mitochondrial integrity of lesioned neurons
Sohn et al., Cancer Res 2006 : p21 blocks irradiation induced apoptosis downstream of mitochondria by inhibition of cyclin dependent kinase mediated caspase-9 activation
Huang et al., J Biochem 2009 : In addition, the inhibition of Cdk5 prevented Bcl-2 phosphorylation and enhanced H ( 2 ) O ( 2 ) -induced caspase-3 activation as well as subsequent DNA fragmentation
Kuo et al., Chin J Physiol 2009 (Uterine Cervical Neoplasms) : In addition, our results also indicated that Cdk5 activity was involved in RA-induced HeLa apoptosis by detecting cleavages of caspase-3 and its substrate, PARP ( poly ( ADP-ribose ) polymerases ) Interestingly, the nuclear localizations of Cdk5 and p35 proteins were increased by RA treatment, which, again, suggests the involvement of Cdk5 and p35 in RA-induced apoptotic effects
Yang et al., Mol Med Report 2010 : The expression of cyclin D1 , cyclin dependent kinase 4 (CDK4), Bcl-2, Bcl-xL and the activation of caspase-3 were examined by Western blotting