UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to HERC5

HERC5 — ISG15

Pathways - manually collected, often from reviews:

Reactome Reaction: ISG15 → HERC5 (direct_complex)
Reactome Reaction: ISG15 → HERC5 (indirect_complex) Zou et al., J Biol Chem 2006 *, Dastur et al., J Biol Chem 2006 *, Wong et al., Proc Natl Acad Sci U S A 2006, Okumura et al., Genes Dev 2007
Reactome Reaction: ISG15 → HERC5 (reaction) Malakhov et al., J Biol Chem 2003, Zhao et al., Proc Natl Acad Sci U S A 2005, Takeuchi et al., Biochem Biophys Res Commun 2005, Zou et al., Biochem Biophys Res Commun 2005, Giannakopoulos et al., Biochem Biophys Res Commun 2005, Zou et al., J Biol Chem 2006 *, Dastur et al., J Biol Chem 2006 *, Takeuchi et al., J Biochem 2005, Wong et al., Proc Natl Acad Sci U S A 2006, Takeuchi et al., FEBS Lett 2006, Lu et al., Cell Mol Biol Incl Cyto Enzymol 2006, Okumura et al., Genes Dev 2007, Jeon et al., EMBO Rep 2009, Zhao et al., Proc Natl Acad Sci U S A 2010 *, Versteeg et al., J Virol 2010 *, Shi et al., Mol Cell Biol 2010, Tang et al., J Immunol 2010 *

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: HERC5 — ISG15 (physical association, affinity chromatography technology) Wong et al., Proc Natl Acad Sci U S A 2006
IRef Biogrid Interaction: HERC5 — ISG15 (physical association, affinity chromatography technology) Zhao et al., Proc Natl Acad Sci U S A 2005

Text-mined interactions from Literome

Dastur et al., J Biol Chem 2006 : Herc5 , an interferon induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells ... These results demonstrate that Herc5 is required for conjugation of ISG15 to a broad spectrum of target proteins in human cells
Wong et al., Proc Natl Acad Sci U S A 2006 : Therefore, this study demonstrates that HERC5/Ceb1 is involved in the conjugation of ISG15 to cellular proteins