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CD40 — IKBKG
Pathways - manually collected, often from reviews:
-
WikiPathways NLR Proteins:
IKBKG/CHUK/IKBKB
→
Complex of RELA-CD40
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Manning et al., Eur J Immunol 2002
:
Engagement of
CD40 by its ligand
induces IKK and mitogen activated protein kinase ( MAPK ) phosphorylation and transcriptional activation, leading to activation and differentiation of B cells
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1 increased constitutive NF-kappa B activity and enhanced
I kappa B kinase (IKK) activation
induced by
CD40 stimulation
Mukundan et al., J Immunol 2005
:
Finally, treatment of monocytes with a cell-permeable peptide corresponding to the TRAF6 binding motif of CD40 inhibited
CD40 activation of ERK1/2,
IKK , and inflammatory cytokine production
Taguchi et al., Genes Cells 2009
:
TRAF6 is essential for osteoclastogenesis and for both RANK- and
CD40 mediated
activation of
IKK and MAPKs