UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to LRP6

DVL3 — LRP6

Pathways - manually collected, often from reviews:

NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5 complex (WNT3A-FZD5-LRP6) → WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) (modification, collaborate)
Schwarz-Romond et al., J Cell Sci 2005, Bilic et al., Science 2007, Zeng et al., Development 2008, Qin et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5 complex (WNT3A-FZD5-LRP6) → DVL (DVL3/DVL1/DVL2) (modification, collaborate) Schwarz-Romond et al., J Cell Sci 2005, Bilic et al., Science 2007, Zeng et al., Development 2008, Qin et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → DVL (DVL3/DVL1/DVL2) (modification, collaborate) Schwarz-Romond et al., J Cell Sci 2005, Bilic et al., Science 2007, Zeng et al., Development 2008, Qin et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Degradation of beta catenin: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) (modification, inhibits)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Degradation of beta catenin: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, inhibits)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
Davidson et al., Nature 2005, Zeng et al., Nature 2005, Zeng et al., Development 2008
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
Zeng et al., Nature 2005, Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → PIP4K2A (PI4K2A) (modification, activates) Pan et al., Science 2008, Qin et al., J Biol Chem 2009
Evidence: assay, physical interaction
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → APC (APC) (modification, collaborate) Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → beta catenin (CTNNB1) (modification, collaborate) Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
Reactome Reaction: DVL3 → LRP6 (direct_complex) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Davidson et al., Nature 2005, Zeng et al., Nature 2005, Bilic et al., Science 2007, MacDonald et al., J Biol Chem 2008
Reactome Reaction: DVL3 → LRP6 (reaction) Wong et al., Mol Cell 2003, Tamai et al., Mol Cell 2004, He et al., Development 2004, Zeng et al., Nature 2005, Fujii et al., Cancer Res 2007, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008, Tauriello et al., Proc Natl Acad Sci U S A 2012
Reactome Reaction: DVL3 → LRP6 (indirect_complex) Wong et al., Mol Cell 2003, Fujii et al., Cancer Res 2007, Zeng et al., Development 2008, Tauriello et al., Proc Natl Acad Sci U S A 2012
WikiPathways ESC Pluripotency Pathways: Complex of 12 proteins → DVL3/DVL1/DVL2 (activation)
WikiPathways Wnt Signaling Pathway and Pluripotency: LDLR/LRP5/LRP6 → DVL3/DVL2/DVL1 (activation)
WikiPathways Wnt Signaling in Kidney Disease: LRP5/LRP6/FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3 → DVL2/DVL3/DVL1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Intact Interaction: Complex of 19 proteins (association, anti bait coimmunoprecipitation) Li et al., Cell 2012

Text-mined interactions from Literome

Zeng et al., Development 2008 : Here we show that both Fz and Dvl functions are critical for Wnt induced Lrp6 phosphorylation through Fz-Lrp6 interaction
Wei et al., Mol Cell Biol 2012 (Wnt Signaling Pathway) : Dvl is required for LRP6 phosphorylation, which is essential for subsequent steps of signal transduction, such as Axin recruitment and cytosolic ß-catenin stabilization