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MET — MMP2
Text-mined interactions from Literome
Torres et al., Clin Cancer Res 2011
(Neoplasm Invasiveness...) :
MET activation increased MPNST cell motility, invasion, angiogenesis, and
induced matrix metalloproteinase-2 (MMP2) and VEGF expression ; MET knockdown had inverse effects in vitro and markedly decreased local and metastatic growth in vivo
Zhang et al., Curr Mol Med 2012
(Breast Neoplasms...) :
Addition of sera obtained from patients treated with combination of radiotherapy and EGCG feeding for 2-8 weeks to in vitro cultures of highly-metastatic human MDA-MB-231 breast cancer cells resulted in the following significant changes : ( 1 ) suppression of cell proliferation and invasion ; ( 2 ) arrest of cell cycles at the G0/G1 phase ; ( 3 ) reduction of
activation of
MMP9/MMP2 , expressions of Bcl-2/Bax,
c-Met receptor, NF-?B, and the phosphorylation of Akt
Baek et al., J Immunol 2012
(Inflammation) :
Additionally, we found that
Met signaling
regulates matrix metalloproteinase
MMP2 and MMP9 activity, which is important for DC migration through extracellular matrix