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MB — MYO10
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Frederiksen et al., J Agric Food Chem 2008
:
Myosin thiols are suggested to be the main target for oxidative modification, as NEM treated
myosin did not form radicals in the
presence of hypervalent
myoglobin
Hanan et al., Eur J Biochem 1995
:
Thus, at cellular ionic strength in which myosin is insoluble, cross linking of
myosin could still be
triggered by
myoglobin and H2O2 ... Based on these data, it is suggested that
myoglobin induced cross linking of
myosin and the consequent loss of adenosinetriphosphatase activity may be involved in muscle malfunction under hypoxia when cellular peroxidants increase and the deoxymyoglobin form prevails