Gene interactions and pathways from curated databases and text-mining

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PLA2G4A — PPARD

Text-mined interactions from Literome

Xu et al., J Biol Chem 2006 (Bile Duct Neoplasms...) : Overexpression or activation of cPLA2alpha enhanced PPARdelta binding to PPARdelta response element ( DRE ) and increased PPARdelta reporter activity, indicating a novel role of cPLA2alpha for PPARdelta activation
Xu et al., Cancer Res 2006 (Carcinoma, Hepatocellular...) : Activation of cPLA(2)alpha by the calcium ionophore A23187 enhanced PPARdelta binding to PPARdelta response element ( DRE ) and increased PPARdelta reporter activity, which was blocked by the selective cPLA(2)alpha inhibitors
Han et al., J Cell Biochem 2008 (Cholangiocarcinoma) : Overexpression of cPLA(2)alpha in human cholangiocarcinoma cells induced the binding of PPARdelta to beta-catenin and increased their association with the TCF/LEF response element