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AKT2 — TERF1

Text-mined interactions from Literome

Tsygankova et al., Mol Cell Biol 2001 : The ability of TSH to stimulate Akt phosphorylation was markedly enhanced by the expression of activated Rap1A and was repressed in cells expressing a putative dominant negative Rap1A mutant ... Although the expression of activated Rap1A was sufficient to stimulate wortmannin-sensitive Akt phosphorylation, TSH further increased Akt phosphorylation in a phosphatidylinositol 3-kinase- and PKA dependent manner
Wang et al., J Biol Chem 2001 : Moreover, inhibition of Rap1 by a Rap1 GTPase activating protein-1 also resulted in a decrease in ERK and Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The role of Rap1 in ERK and Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Romano et al., Endocrinology 2006 : Under the same conditions, PI3K and Akt inhibition also both increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Edreira et al., J Biol Chem 2009 : cAMP dependent protein kinase (PKA) mediated phosphorylation of Rap1b is required for cAMP dependent mitogenesis, tumorigenesis, and inhibition of AKT activity
Malchinkhuu et al., Mol Biol Cell 2009 (Glioma) : The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and Rap1B mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA
Tawa et al., Circ Res 2010 (Disease Models, Animal...) : Rap1 regulated the interaction between afadin and phosphatidylinositol 3-kinase (PI3K), recruitment of the afadin-PI3K complex to the leading edge, and the activation of Akt , indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway