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IL8 — PTGS2

Text-mined interactions from Literome

Fosslien et al., Ann Clin Lab Sci 2000 (Carcinoma, Squamous Cell...) : COX-2 is inducible by oncogenes ras and scr, interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha
Stanford et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : Cyclooxygenase-2 regulates granulocyte-macrophage colony stimulating factor, but not interleukin-8 , production by human vascular cells : role of cAMP ... Under the same conditions, we found that COX-2 activity suppressed GM-CSF, but not IL-8 , release by both types of human vascular cells
Fong et al., Am J Physiol Lung Cell Mol Physiol 2000 : In this study, we tested the ability of transforming growth factor (TGF)-beta1 to stimulate IL-8 release, cyclooxygenase (COX)-2 expression and PGE ( 2 ) generation in cultured human ASM cells and explored the role of COX products and COX-2 induction on IL-8 release ... TGF-beta1 stimulated IL-8 release, COX-2 induction , and PGE ( 2 ) generation in a concentration- and time dependent manner ... These results show for the first time that TGF-beta1 stimulates IL-8 release, COX-2 induction , and PGE ( 2 ) generation in human ASM cells and that PGE ( 2 ) generation is not critical for TGF-beta1 induced IL-8 release
Nédélec et al., Biochem Pharmacol 2001 : In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Konturek et al., Dig Dis Sci 2003 (Helicobacter Infections...) : ( 4 ) COX-2, PPARgamma, Bcl-2, and survivin were overexpressed in gastric tumor, but the inhibition of COX-2 activity by Vioxx resulted in a significant reduction in serum and tumor levels of progastrin and gastrin and serum IL-8 and TNF-alpha levels, suggesting that gastrin and proinflammatory cytokines could mediate the up-regulation of COX-2 in gastric cancerogenesis
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Varro et al., Cancer Res 2004 (Neoplasm Invasiveness...) : The induction of PAI-2 by H. pylori was mediated by release of interleukin-8 and activation of cyclooxygenase-2 , and interestingly, gastrin stimulated PAI-2 expression by similar paracrine pathways
Põld et al., Cancer Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer
Santos et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase independent pathways
Stamp et al., J Rheumatol 2004 : Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes : role of interleukin 17 and interferon-gamma
Manna et al., J Biol Chem 2005 : IL-8 induces NF-kappaB dependent reporter gene expression as well as ICAM-1, VCAM-1, and Cox-2 expression
Attar et al., Hum Reprod Update 2006 (Endometriosis...) : COX-2 in turn is stimulated by E ( 2 ), interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Iwase et al., Int Immunopharmacol 2006 : Moreover, NS-398 suppressed the anti-apoptotic activity of IL-8 and IL-1beta, but did not induce COX-2 ; therefore, the pro-apoptotic mechanism of the selective COX-2 inhibitor may be unrelated to COX-2 activity
Singh et al., J Surg Res 2006 (Bone Neoplasms...) : COX-2 overexpression caused a 4- to 5-fold increase in IL-8 production in both MCF-10A and MDA-231 cells in vitro ... Treatment with the COX-2 inhibitor NS-398 at a low 1-mu [ scap ] M dose reduced the production of IL-8 in COX-2 transfected MDA-231 cells by 30 %, thus confirming the involvement of COX-2 in IL-8 induction ... COX-2 expression induced formation of PGE2 and IL-8 in breast cancer cells
Takehara et al., Dig Dis Sci 2006 (Adenocarcinoma...) : We examined the effects of H pylori stimulation on IL-8 and COX-2 expression levels and the effects of COX-2 inhibitor on H pylori induced IL-8 production in the MKN45 cells and gastric fibroblasts
Wu et al., Hepatogastroenterology 2006 (Stomach Ulcer) : H. pylori did not alter COX-2 and local cytokine expressions in gastric ulcer, but induced IL-8 and COX-2 in antral mucosa
Wu et al., Prostaglandins Other Lipid Mediat 2007 : In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters ( PMA ), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007 (Endometriosis) : These results, along with recent findings that TSA suppresses proliferation, interleukin-1 beta induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
Nieves-Alicea et al., Breast Cancer Res Treat 2009 (Breast Neoplasms...) : Here we report the novel findings that suppression of PDCD4 expression is vital for the invasive activity of COX-2 mediated by PGE ( 2 ) and IL-8 , and that PDCD4 increases TIMP-2 expression to inhibit breast cancer cell invasion
Zhu et al., BMC cancer 2008 (Carcinoma, Non-Small-Cell Lung...) : Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells ... We speculated that inhibition of COX-2 activity might reduce expression of the pro-angiogenic factors vascular endothelial growth factor ( VEGF ) and interleukin-8 (IL-8) in lung cancer cells
Bachawaty et al., Reprod Sci 2010 (Pre-Eclampsia) : To study the role of COX-2 in IL-8 production, neutrophils of normal pregnant women were activated with arachidonic acid ( AA ) and incubated overnight in Medium 199 with and without NS398, a specific COX-2 inhibitor
Vinukonda et al., Brain 2010 (Disease Models, Animal...) : Cyclooxygenase-2 or prostanoid receptor-1 inhibition reduced tumour necrosis factor-a level, but not interleukin-1ß
Matesanz et al., J Nutr Biochem 2012 : These results suggest that linoleic acid induced changes in monocyte chemotaxis and subsequent binding are not solely mediated by changes in adhesion molecule expression but may be due to secreted factors such as IL-8, monocyte chemoattractant protein-1 or prostaglandins (PGs) such as PGE ( 2 ), as IL-8 neutralisation and COX-2 inhibition reduced monocyte binding without changes in adhesion molecule expression
Martín et al., J Hypertens 2012 : PPAR? activation with pioglitazone reduces interleukin-1ß induced COX-2 expression by interference with the redox-sensitive transcription factor NF-?B ... This study analyzes the effect of pioglitazone, a PPAR? agonist, on interleukin-1ß induced COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Kim et al., Microbiol Immunol 2013 : Furthermore anthocyanins inhibited H. pylori induced inducible nitric oxide synthases and cyclooxygenase-2 mRNA expression and inhibited IL-8 production by 45.8 %
Szczepanski et al., Arthritis Rheum 1994 : Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1
Feng et al., Arch Biochem Biophys 1993 : In rat vascular smooth muscle cells, interleukin-1 beta selectively increased the expression of COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Crofford et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
Kniss et al., Am J Obstet Gynecol 1997 : Interleukin-1 receptor antagonist blocks interleukin-1 induced expression of cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress interleukin-1 induced cyclooxygenase-2 expression
Maloney et al., J Immunol 1998 : COX-2 was induced in a time- and concentration dependent fashion when isolated human PMNs were exposed to LPS ; COX-2 was also induced , or its expression was increased, by TNF-alpha, IL-1, and IL-8
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Longo et al., Mediators Inflamm 1998 : The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation