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BIRC6 — CASP12

Text-mined interactions from Literome

Bartke et al., Mol Cell 2004 : By using wild-type and mutant forms we show that BRUCE inhibits caspase activity and apoptosis depending on its BIR domain
Qiu et al., J Biol Chem 2005 : Through these associations, BRUCE promotes the degradation of Smac and inhibits the activity of caspase-9 but not the effector caspase, caspase-3
Das et al., Cancer 2007 (Glioblastoma) : Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and activation of calpain, caspase-9 , and caspase-3
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Karmakar et al., Neuroscience 2009 (Body Weight...) : Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing ( BIRC ) proteins including BIRC-2 and BIRC-3, and activation of caspase-3 and apoptosis inducing factor ( AIF )