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CASP12 — DISC1

Text-mined interactions from Literome

Scaffidi et al., Methods 1999 : DISC formation is the first essential step of CD95 signaling and results in activation of caspase-8 starting a signaling cascade that leads to apoptosis
Hennino et al., J Immunol 2000 : We report here that Fas induced apoptosis in B cells does not require integrity of the mitochondrial Apaf-1 pathway and that caspase-8 is activated by association with the death inducing signaling complex ( DISC ), i.e., upstream of the mitochondria
Gómez-Angelats et al., J Biol Chem 2001 : PKC activation blocked FADD recruitment and caspase-8 activation and thus DISC formation in both type I and II cells
Stegh et al., J Biol Chem 2002 (Breast Neoplasms) : We now demonstrate that active caspase-8 is initially generated at the DISC of both MCF7-Fas-Vec and MCF7-Fas-Bcl-x ( L ) cells and that the early steps of CD95 signaling such as caspase-8 dependent cleavage of DISC bound c-FLIP ( L ), caspase-8 dependent clustering, and internalization of CD95, as well as processing of pro-caspase-8 bound to mitochondria are very similar in both transfectants
Srivastava et al., Neoplasia (New York, N.Y.) 2001 (Neoplasms) : The major pathway of its action proceeds through the formation of DISC and activation of caspase-8
Rokhlin et al., Cancer Biol Ther 2004 (Prostatic Neoplasms) : Our data also show that impaired TRAIL-DISC formation in the presence of TPCK is responsible for caspase inhibition
Kohlhaas et al., J Biol Chem 2007 : Our findings demonstrate that TRAIL and TRAIL receptor 1/2, unlike TNF-TNF-R1 or CD95L-CD95, do not require internalization for formation of the DISC , activation of caspase-8 , or transmission of an apoptotic signal in BJAB type I cells
Chen et al., J Cell Biochem 2008 (Bile Duct Neoplasms...) : TFP decreased DISC induced cleavage of caspase-8
Olsson et al., Oncogene 2009 : DISC mediated activation of caspase-2 in DNA damage induced apoptosis
Jin et al., Cell 2009 : While DISC recruitment initiates caspase-8 stimulation, full activation of the protease depends on further molecular aggregation events that are not fully understood
Carlisi et al., Eur J Cancer 2009 (Carcinoma, Hepatocellular...) : These two modifications provoked in the presence of TRAIL the rapid production of TRAIL-DISC and the activation of caspase-8
Bunek et al., Oral Dis 2011 (Carcinoma, Squamous Cell...) : In death receptor mediated anoikis mechanisms, focal adhesion kinase ( FAK ) and receptor interacting protein ( RIP ) dissociate, leading to association of RIP with Fas, formation of the death inducing signaling complex ( DISC ), activation of caspase-3 , and propagation of anoikis
Kober et al., Cell death & disease 2011 (MAP Kinase Signaling System) : We found that CD95 DISC induced caspase-8 activity is important for the initiation of ERK1/2 and p38 MAPK activation