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CD79B — HCK
Text-mined interactions from Literome
Lionberger et al., J Biol Chem 2000
(Leukemia, Myeloid) :
Recent work shows that
Hck , a member of the Src tyrosine kinase family with myeloid restricted expression, associates with and is
activated by
Bcr-Abl
Poincloux et al., J Cell Physiol 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In chronic myeloid leukemia ( CML ), the transforming activity of
Bcr/Abl involves constitutive activation of the phagocyte specific Src-family tyrosine kinase
Hck , which in turn directly activates the signal transducer and activator of transcription 5 ( STAT5 )
Pene-Dumitrescu et al., J Biol Chem 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
NaPP1 also reduced
Hck mediated phosphorylation of
Bcr-Abl at sites that may affect imatinib sensitivity exclusively in cells expressing Hck-T338A
Warmuth et al., J Biol Chem 1997
:
Neither the complex formation of Hck kinase with Bcr-Abl nor the
activation of
Hck by
Bcr-Abl was dependent on the Abl kinase activity