We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to CTNNB1

CTNNB1 — NFKB1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Spiegelman et al., Oncogene 2002 : In the NIH3T3 cells, which express HOS, but not betaTrCP, Wnt/beta-catenin signaling leads to inhibition of HOS promoter activity and NF-kappaB-driven transcription as well as to stabilization of beta-catenin
Tselepis et al., Oncogene 2002 (Adenocarcinoma...) : This beta-catenin mediated transcription is independent of NF-kappaB activation
Deng et al., Cancer Cell 2002 (Breast Neoplasms...) : beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer ... Importantly, activated beta-catenin was found to inhibit the expression of NF-kappa B target genes, including Fas and TRAF1 ... Furthermore, a strong inverse correlation was identified between the expression levels of beta-catenin and Fas in colon and breast tumor tissues, suggesting that beta-catenin regulates NF-kappa B and its targets in vivo
Deng et al., Mol Carcinog 2004 : beta-catenin has been recently found to interact with and inhibit nuclear factor kappa B (NF-kappaB)
Kuphal et al., Oncogene 2004 (Melanoma) : Furthermore, cytoplasmatic beta-catenin induced p38 and NFkappaB activation in malignant melanoma ... In summary, we conclude that loss of E-cadherin and cytoplasmatic beta-catenin induces p38 mediated NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas
Zuscik et al., Environ Health Perspect 2007 : Although Pb had no effect on basal CREB or Wnt/beta-catenin pathway activity, it induced NFkappaB signaling and inhibited AP-1 signaling
Cho et al., FEBS Lett 2008 (Neoplasms) : Downregulation of lzts2 increased the beta-catenin/Tcf promoter activity and inhibited NF-kappaB induced modulation of the nuclear translocation of beta-catenin
Zhang et al., Dev Cell 2009 : We find that Wnt/beta-catenin signaling is absolutely required for NF-kappaB activation, and that Edar is a direct Wnt target gene