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CEP97 — FLT3

Text-mined interactions from Literome

Smith et al., Blood 2004 (Acute Disease...) : Single-agent CEP-701 , a novel FLT3 inhibitor , shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
Levis et al., Blood 2004 (Acute Disease...) : CEP-701 , an indolocarbazole derived selective FLT3 inhibitor , potently induces apoptosis in FLT3/ITD expressing cell lines and primary leukemic blasts
Brown et al., Blood 2004 (Leukemia, Myeloid, Acute) : In this study, cytotoxicity and apoptosis assays were performed on 44 diagnostic pediatric AML blast samples ( 14 FLT3/WT, 15 FLT3/ITD, 15 FLT3/PM ) using CEP-701 , a potent and selective FLT3 inhibitor
Brown et al., Blood 2005 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : We determined the antileukemic activity of CEP-701 , a potent and selective FLT3 inhibitor , in 8 ALL cell lines and 39 bone marrow samples obtained at diagnosis from infants and children with various subtypes of ALL
Knapper et al., Blood 2006 (Acute Disease...) : We studied the effects of lestaurtinib ( CEP701 ) and PKC412, 2 small molecule inhibitors of FLT3 , on 65 diagnostic AML blast samples