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FOS — IFNG

Pathways - manually collected, often from reviews:

• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species

Text-mined interactions from Literome

Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Hamada et al., Toxicology 2000 : However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with rMu-IFN-gamma + Be increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of AP-1 and CREB at 15 h, however, only Jun B was increased
Robertson et al., Brain Res Bull 2000 : IFN-gamma induced Fos expression mostly corresponded to neuronal sites of receptor distribution
Kim et al., J Immunol 2000 : EMSA using an AP-1-specific oligonucleotide demonstrated that IFN-gamma or LPS treatment increased the AP-1 binding activity
Nakahira et al., J Immunol 2002 : These results show that STAT4 up-regulates AP-1 mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18 induced synergistic enhancement of IFN-gamma gene expression
Kaminuma et al., FEBS Lett 2002 : Vav induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity
Hosono et al., Biosci Biotechnol Biochem 2003 : IgA secretion by Peyer 's patch ( PP ) cells was upregulated in a dose dependent way in response to FOS and CD4+ T cells from PP showed a dose dependent increase in production of interferon-gamma and interleukin (IL) 10, and a high response in production of IL-5 and IL-6
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB ... Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : Although LPS and IFN-gamma alone marginally activated nuclear factor (NF)-kappaB but not AP-1, LPS plus IFN-gamma augmented NF-kappaB and AP-1
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma
Bae et al., Planta Med 2006 : Electrophoretic mobility shift assays revealed that ginsenoside Rh2 significantly inhibited the LPS/IFN-gamma induced AP-1 DNA binding activity, while it enhanced the protein binding to CRE sequences
Hu et al., Immunity 2006 (Arthritis...) : IFN-gamma suppressed the activity of CREB and AP-1 , transcription factors that induce IL-10 expression and are regulated in part by MAPKs and GSK3
Gough et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Herein we have shown that IFNgamma rapidly activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1 ... IFNgamma induced c-Jun phosphorylation and AP-1 DNA binding required the MEK1/2 and ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen activated protein kinase pathways were dispensable ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs
Deng et al., Arterioscler Thromb Vasc Biol 2007 : IFNgamma blocked C-Jun and C/EBPbeta but not C-Fos or p50 NF-kappaB binding as determined by in vitro binding assays and chromatin immunoprecipitation assay
Andrade et al., Prostaglandins Leukot Essent Fatty Acids 2007 : The FO-S resulted in an increase in LCPUFA n-3 and a decrease in arachidonic n-6 FA in plasma and a reduction in the production of interferon-gamma by cultured cells
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma , TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Do et al., J Nutr Biochem 2010 (Brain Neoplasms...) : In addition, fucoidan inhibited TNF-alpha- and IFN-gamma induced AP-1 , IRF-1, JAK/STAT and p38 mitogen activated protein kinase ( MAPK ) activation and induced scavenger receptor B1 (SR-B1) expression
Jung et al., Int Immunopharmacol 2010 : Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma induced NF-kappaB and AP-1 activity
de Wit et al., Exp Hematol 1996 : We conclude that the effects of IFN-gamma on the expression of the transcription factors AP-1 and NF-kappa B may be important for the modulatory effects of IFN-gamma on the cytokine expression in activated human monocytes
Barbulescu et al., J Immunol 1998 : These data suggest that both AP-1 and STAT4 are required for IL-12 dependent IFN-gamma promoter activity, whereas IL-18 causes direct activation via AP-1