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IGF1 — TGFB2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IGF1 → TGFB2 (decreases, TGFB2 Activity)
  Evidence: IGFbPs limit IGF access to IGF1R, thereby attenuating the bioactivity of these growth factors33. The tumour suppressor p53 (REF. 34), as well as many growth inhibitors including vitamin d35, anti- oestrogens36, retinoids37, and transforming growth factor-? (TGF?37), reduce IGF bioactivity by increasing the secretion of IGFbPs33.

Text-mined interactions from Literome

Richardson et al., Acta Anat (Basel) 1992 : Effect of transforming growth factor-beta on insulin-like growth factor 1- and dexamethasone induced proliferation and differentiation in primary cultures of pig preadipocytes
Daian et al., J Invest Dermatol 2003 (Keloid) : Insulin-like growth factor-I enhances transforming growth factor-beta induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts ... These results indicate that insulin-like growth factor-I enhances transforming growth factor-beta induced keloid formation through transforming growth factor-beta postreceptor signal cross-talk, mainly via the p38 mitogen activated protein kinase/activating transcription factor-2 pathway
Song et al., EMBO J 2006 : Insulin-like growth factor-I inhibits transforming growth factor-beta ( TGF-beta ) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt dependent pathway
Izumi et al., Invest Ophthalmol Vis Sci 2006 : TGF-beta2 treatment induced expression of IGF-I and IGFBP-3 mRNA and of IGFBP-3 protein in human corneal fibroblasts
Magoffin et al., Endocrinology 1989 : These results lead us to conclude that 1 ) the TIC are targets for TGF beta; 2 ) IGF-I increases the sensitivity of TIC to TGF beta action ; and 3 ) TGF beta acts directly on TIC to stimulate progesterone while inhibiting androgen production
Mondschein et al., Endocrinology 1988 : Effects of transforming growth factor-beta on the production of immunoreactive insulin-like growth factor I and progesterone and on [ 3H ] thymidine incorporation in porcine granulosa cell cultures
Okazaki et al., Biochem Biophys Res Commun 1995 : Previous studies in rat osteoblastic cells have indicated that transforming growth factor-beta ( TGF-beta ) inhibits IGF-I expression, whereas inducers of intracellular cAMP stimulate IGF-I expression
Wikiel et al., Biochim Biophys Acta 1994 (Leukemia, Myeloid, Acute) : In the absence of serum, growth of ML-1 human myeloblastic leukemia cells is induced by the insulin-like growth factor-1 (IGF1) together with transferrin (Tf), whereas monocytic differentiation is initiated by the transforming growth factor-beta ( TGF-beta ) in combination with Tf. Initiation of growth was followed by the rapid release of arachidonic acid ( AA ), hydroxyeicosatetraenoic acids ( HETEs ) and phospholipids into the culture medium
Gucev et al., Cancer Res 1996 (Breast Neoplasms) : Both RA and TGF-beta2 increased the levels of insulin-like growth factor binding protein ( IGFBP) 3 (2-3-fold ) and mRNA ( 1.5-2-fold ), whereas IGFBP-4 levels remained essentially unchanged