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NOXA1 — PRKACG
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Kroviarski et al., FASEB J 2010
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Here we report that NOX1 activity is regulated through MAP kinase ( MAPK ), protein kinase C ( PKC ), and
protein kinase A (PKA) dependent phosphorylation of
NOXA1
Henri et al., J Cell Physiol 2012
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We then assessed ROS production immediately after UVA exposure and found that : ( 1 ) UVA-ROS production was strongly reduced in HaCaT-MC1R but not in HaCaT-R ( 151 ) C cells compared to parental HaCaT cells ; ( 2 ) this inhibitory effect was further amplified by incubation of HaCaT-MC1R cells with a-MSH before UVA exposure ; ( 3 )
protein kinase A (PKA) dependent
NoxA1 phosphorylation was increased in HaCaT-MC1R compared to HaCaT and HaCaT-R ( 151 ) C cells