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AKT3 — CTNNB1

Text-mined interactions from Literome

Yuan et al., J Biol Chem 1999 : We investigated the effect of an activated Akt on the accumulation of cytosolic beta-catenin and LEF-1 dependent transcription ... Although the activated Akt , mAkt, clearly inhibited the kinase activity of GSK, mAkt alone did not induce accumulation of cytosolic beta-catenin or activate LEF-1 dependent transcription
Sharma et al., J Biol Chem 2002 (Prostatic Neoplasms) : Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation
Tian et al., Proc Natl Acad Sci U S A 2004 : More importantly, 14-3-3zeta facilitates activation of beta-catenin by the survival kinase Akt and colocalizes with activated Akt in intestinal stem cells
Tian et al., Cell cycle (Georgetown, Tex.) 2005 : Thus, Akt may contribute to activation of beta-catenin in ISCs in coordination with Wnt signaling ... By conducting a proteomic analysis of the beta-catenin complex, we show that 14-3-3zeta exists in the beta-catenin complex and facilitates activation of beta-catenin by Akt , which, intriguingly, appears to be predominantly in ISCs
Dash et al., Cell Signal 2005 : We suggest that the Akt mediated activation of beta-catenin leads to inhibition of trophoblast apoptosis following increased expression of iNOS
Abbosh et al., Thyroid 2005 (Thyroid Neoplasms) : Activation of AKT by phosphatidylinositide-3 kinase (PI3K), a RAS effector, results in GSK3beta phosphorylation and deactivation and subsequent beta-catenin upregulation in thyroid cancer
Almeida et al., J Biol Chem 2005 : Wnt3a induced phosphorylation of GSK-3beta and downstream activation of beta-catenin mediated transcription required ERK, PI3K, and Akt signaling
Ishibe et al., Mol Cell Biol 2006 : In nonconfluent cells treated with HGF, the high level of Akt activation resulted in inhibitory phosphorylation of glycogen synthase kinase 3beta ( GSK-3beta ) and increased beta-catenin nuclear signaling
Fang et al., J Biol Chem 2007 (Neoplasm Invasiveness...) : AKT mediated phosphorylation of beta-catenin causes its disassociation from cell-cell contacts and accumulation in both the cytosol and the nucleus and enhances its interaction with 14-3-3zeta via a binding motif containing Ser552 ... Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT dependent regulation of beta-catenin plays a critical role in tumor invasion and development
LaMarca et al., Hum Reprod 2008 : Although Akt activation leads to GSK-3beta phosphorylation and the subsequent expression of beta-catenin , activation of this pathway by 1-azakenpaullone was insufficient to stimulate the motile phenotype
Chung et al., J Endocrinol 2008 : Our data also suggest that PI3K/Akt mediated inactivation of GSK-3beta and stabilization of beta-catenin contribute to the anti-apoptotic effects of ghrelin
Siler et al., Virology 2008 : The nuclear translocation, but not accumulation of beta-catenin was dependent on Akt activation
Bedel et al., Circ Res 2008 (Atherosclerosis...) : The concomitant phosphatidylinositol 3-kinase/Akt activation and glycogen synthase kinase 3-beta phosphorylation induced the inhibition of the proteasomal degradation of beta-catenin
Espada et al., J Cell Physiol 2009 : This protective effect is associated with beta-catenin dependent transcription and with activation of survival factor Akt/PKB
Hong et al., J Exp Clin Cancer Res 2009 (Carcinoma, Squamous Cell...) : This study aimed to investigate whether Akt inhibition would restore the expression of E-cadherin and beta-catenin , reduce that of Vimentin, and induce the MErT in OSCC cells with low or negative expression of E-cadherin
Saegusa et al., Am J Pathol 2009 (Carcinosarcoma...) : In endometrial cancer cell lines, active Akt induced the stabilization of nuclear beta-catenin through the phosphorylation of GSK-3beta, and this, in turn, led to the transactivation of Slug, which was mediated by nuclear beta-catenin
Lee et al., Stem Cells 2009 : BMP-4 induced beta-catenin activation and cyclin D1 expression were attenuated by phosphatidyl inositol 3-kinase (PI3K) siRNA and Akt inhibitor
Wang et al., J Am Soc Nephrol 2009 : Because Akt regulates Bax, we examined the effects of the beta-catenin mutants on Akt expression and activation ... Constitutively active beta-catenin increased Akt-1 expression and activation before and after stress, and treatment with a phosphatidylinositol-3 kinase inhibitor antagonized the protective effects of beta-catenin on Akt activation, Bax inhibition, and cell survival
Xia et al., Mol Cell Biol 2010 : Interestingly, the activation of PI3K/Akt appeared to be independent of the activation of PKA, whereas both PI3K/Akt and PKA signaling inactivated GSK-3 and increased beta-catenin translocation
Robertson et al., Exp Cell Res 2010 (Prostatic Neoplasms) : Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells
Sunters et al., J Biol Chem 2010 : Mechano-transduction in osteoblastic cells involves strain regulated estrogen receptor alpha mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT dependent Wnt/LRP5 receptor independent activation of beta-catenin signaling ... These data suggest an initial cascade of strain related events in osteoblasts in which strain activates IGF-IR, in association with ERalpha, so initiating phosphatidylinositol 3-kinase/AKT dependent activation of beta-catenin and altered lymphoid enhancing factor/T cell factor transcription
Venkatesan et al., Cell Signal 2010 : Further, WISP1 stimulates PI3K-Akt dependent GSK3beta phosphorylation and beta-catenin nuclear translocation
Wang et al., J Bone Miner Res 2010 : T ( 3 ) -mediated Wnt-4 expression, beta-catenin activation, cell proliferation, and terminal differentiation of growth plate chondrocytes are partially prevented by the IGF1R inhibitor picropodophyllin as well as by the PI3K/Akt signaling inhibitors LY294002 and Akti1/2
Nava et al., Immunity 2010 (Colitis) : Short-term exposure of intestinal epithelial cells to IFN-gamma resulted in activation of beta-catenin through AKT , followed by induction of the secreted Wnt inhibitor Dkk1
Lee et al., Gastroenterology 2010 (Colitis...) : We investigated whether phosphoinositide 3-kinase (PI3K) is required for Akt mediated activation of beta-catenin during intestinal inflammation ... Biochemical analyses indicated that PI3K-Akt signaling increased nuclear total beta-catenin and P-beta-catenin ( 552 ) levels and reduced N-terminal beta-catenin phosphorylation, which is associated with degradation
Zhang et al., Neural development 2013 : AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development