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AKT3 — VWF
Text-mined interactions from Literome
Mu et al., Blood 2008
:
Deleting these, but not upstream sequences of GPIb alpha expressed in CHO cells, inhibited
VWF/ristocetin dependent
Akt phosphorylation, relative to wild-type receptor, confirming this region encompassed a functional PI3-kinase binding site
Zhang et al., Gastroenterology 2009
(Disease Models, Animal...) :
Following CBDL, but not TAA exposure, rats developed HPS that was temporally correlated with increased numbers of lung microvessel ; increased levels of
vWf , VE-cadherin and PCNA ; and
activation of
Akt and eNOS
Delaney et al., Arterioscler Thromb Vasc Biol 2012
:
von Willebrand factor/GPIb-IX interaction sequentially
activates the Src family kinase Lyn (SFK), phosphoinositide 3-kinase (PI3K), and
Akt , leading to activation of integrin a ( IIb ) ß ( 3 ) and integrin dependent stable platelet adhesion and aggregation