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AKT1 — F2R
Text-mined interactions from Literome
Sabri et al., Circ Res 2002
:
Activation of PAR-1 leads to an increase in Src, Fyn, and epidermal growth factor receptor (EGFR) phosphorylation, with EGFR receptor transactivation by Src family kinases the major mechanism for
PAR-1 dependent activation of extracellular signal regulated kinase, p38-mitogen activated protein kinase, and
protein kinase B ... PAR-1 signaling is highly contextual in nature, inasmuch as
PAR-1 activates extracellular signal regulated kinase and only weakly
stimulates protein kinase B via a pathway that does not involve EGFR transactivation in cardiomyocytes
Salah et al., Mol Cancer Res 2007
(Disease Progression...) :
The activation of
PAR1 induced
pAkt/protein kinase B abrogated serum deprived Bim ( EL ) induction and also markedly inhibited Bax levels
Reséndiz et al., Journal of thrombosis and haemostasis : JTH 2007
:
Stimulation of
PAR1 or PAR4
resulted in rapid
Akt phosphorylation, independently of secreted ADP and phosphatidylinositol-3-kinase (PI3K) activation
Dickey et al., Proc Natl Acad Sci U S A 2008
(Alzheimer Disease) :
Akt enhances the activity of
PAR1 to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 complex
Maeda et al., Brain Res 2009
:
In addition,
Akt phosphorylation caused by plasmin was inhibited in the
presence of
PAR-1 inhibitor