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BCL2 — SIRT1

Text-mined interactions from Literome

Zhou et al., J Pharmacol Sci 2006 : Silibinin increased the expression of anti-apoptotic Bcl-2 family protein Bcl-2 , and up-regulation of SIRT1 inhibited the translocation of Bax from cytoplasm to mitochondria, which caused mitochondrial dysfunction and cell injury
Zhou et al., Yao Xue Xue Bao 2007 : Silibinin increased the expression of anti-apoptotic Bcl-2 family protein Bcl-2 , and up-regulation of SIRT1 inhibited the translocation of Bax from cytoplasm to mitochondria, which caused mitochondrial dysfunction and cell injury
Hsu et al., Circulation 2010 (Myocardial Reperfusion Injury) : Sirt1 positively regulates expression of prosurvival molecules, including manganese superoxide dismutase, thioredoxin-1, and Bcl-xL , whereas it negatively regulates the proapoptotic molecules Bax and cleaved caspase-3
Seo et al., Neurobiol Aging 2012 : SIRT1 activation also inhibited PrP ( 106-126 ) -mediated p38 mitogen activating protein kinase ( MAPK ) activation and caspase-3 cleavage, and increased the expression of anti-apoptotic Bcl-xL protein
Yan et al., J Cereb Blood Flow Metab 2013 (Brain Ischemia) : Besides, SirT1 increased B-cell lymphoma 2 (Bcl-2) expression and decrease cleaved caspase 3