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Kilic et al., CNS Drug Rev 2005
(Brain Ischemia...) :
When administered after optic nerve transection and focal cerebral ischemia, TAT-GDNF protected retinal ganglion cells and brain neurons from cell death, elevated tissue Bcl-XL levels and attenuated the activity of the executioner caspase-3 Yu et al., J Neurosci Res 2007
(Ischemia) :
Moreover, GDNF reduced caspase-3 activity but not that of caspase-1 in cultured astrocytes after ischemia treatment
Subramaniam et al., Cell Tissue Res 2008
:
GDNF alone prevents low-potassium induced caspase-3 activation and DNA fragmentation but does not affect either low-potassium induced ERK activation or PM damage