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CASP4 — ITCH

Text-mined interactions from Literome

Azakir et al., FEBS J 2010 : Consistently, overexpression of Itch increases cell survival and inhibits caspase 3 activity, whereas downregulation of Itch by RNA interference has the opposite effect, increasing cell death and apoptosis
Schlatter et al., PloS one 2011 : In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch mediated cFLIP degradation and predominantly caspase-8 activation is not involved