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CASP7 — PRKCD
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Basu et al., Biochemistry 1999
:
Rottlerin, an inhibitor of
nPKCdelta ,
blocked caspase-3 activation and proteolytic cleavage of nPKCdelta by cDDP
Reyland et al., J Biol Chem 1999
:
Here we report that apoptosis results in the
caspase dependent cleavage of
protein kinase C-delta (PKCdelta) to a 40-kDa fragment, the appearance of which correlates with a 9-fold increase in PKCdelta activity
Koriyama et al., Cell Signal 1999
:
Proteolytic
activation of
protein kinase C delta and epsilon by
caspase-3 in U937 cells during chemotherapeutic agent induced apoptosis
Webb et al., Apoptosis 2000
(Inflammation) :
Spontaneous neutrophil apoptosis does not require Fas ligation, but is mediated by caspases 3, 8 and possibly
caspase 9 and also
involves activation of
protein kinase C-delta
Denning et al., Cell Death Differ 2002
:
The induction of apoptosis in human keratinocytes by UV radiation involves
caspase mediated cleavage and activation of
protein kinase C delta (PKCdelta)
Mohamed et al., Biochem J 2002
(MAP Kinase Signaling System) :
Inhibition in HeLa cells of caspase function by pharmacological inhibitors or the expression of CrmA ( cytokine response modifier A ), a viral modifier protein, blocks TNF induced apoptosis or
caspase dependent
protein kinase Cdelta and poly ( ADP-ribose ) polymerase protein degradation
Kitazawa et al., Neuroscience 2003
(Parkinsonian Disorders) :
Dieldrin induces apoptosis by promoting
caspase-3 dependent proteolytic cleavage of
protein kinase Cdelta in dopaminergic cells : relevance to oxidative stress and dopaminergic degeneration
Kaul et al., Eur J Neurosci 2003
(Nerve Degeneration) :
In the present study, we demonstrate that
caspase-3 mediated proteolytic
activation of
protein kinase C delta (PKC delta) is critical in MPP+ induced oxidative stress and apoptosis
Yang et al., Mol Cell Neurosci 2004
(Nerve Degeneration) :
Suppression of
caspase-3 dependent proteolytic activation of
protein kinase C delta by small interfering RNA prevents MPP+ induced dopaminergic degeneration ... Using RNA interference ( RNAi ), we demonstrate that
caspase-3 dependent proteolytic activation of
protein kinase Cdelta (PKCdelta) contributes to the degenerative process in dopaminergic neurons
Kitazawa et al., Neurotoxicology 2004
:
We also demonstrated that
protein kinase Cdelta (PKCdelta) , a member of a novel PKC family of proteins, is proteolytically
activated by
caspase-3 to mediate apoptotic cell death processes
Voss et al., J Biol Chem 2005
(Inflammation) :
Regulation of monocyte apoptosis by the
protein kinase Cdelta dependent phosphorylation of
caspase-3
Hanrott et al., Eur J Neurosci 2008
:
In an in vitro cellular model, we reported that 6-hydroxydopamine ( 6-OHDA ) induces apoptotic cell death via the induction of mitochondrial dysfunction, the
activation of
caspase 3 and the consequent proteolytic activation of the redox-sensitive kinase,
protein kinase C (PKC)delta , in PC12 cells
Kanthasamy et al., Molecular brain 2008
(Nerve Degeneration...) :
Environmental neurotoxin dieldrin induces apoptosis via
caspase-3 dependent proteolytic activation of
protein kinase C delta (PKCdelta) : Implications for neurodegeneration in Parkinson 's disease ... Furthermore, dieldrin caused the
caspase dependent proteolytic cleavage of
protein kinase C delta ( PKCd ) into 41 kDa catalytic and 38 kDa regulatory subunits in N27 cells as well as in brain slices
Cunningham et al., Endocrinology 2009
:
Androgens induce dopaminergic neurotoxicity via
caspase-3 dependent activation of
protein kinase Cdelta
Zhang et al., Toxicol Appl Pharmacol 2011
:
We previously demonstrated that
caspase-3 dependent proteolytic activation of
protein kinase C delta ( PKCd ) plays a key role in Mn-induced apoptotic cell death in dopaminergic neurons
Arango et al., Biochem Pharmacol 2012
:
Apigenin induced DNA damage was mediated by p38 and
protein kinase C-delta ( PKCd ), yet was
independent of reactive oxygen species or
caspase activity