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PLA2G4A — UTP18

Text-mined interactions from Literome

Ishida et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : Mesenteric arteries from GK rats treated with losartan exhibited ( vs. untreated GK ) 1 ) reduced nucleotide induced contractions, 2 ) suppressed UTP induced release of PGE ( 2 ) and PGF ( 2a ), 3 ) suppressed UTP stimulated cPLA(2) phosphorylation, 4 ) normalized expressions of COX-2 and P2Y4 receptors, and 5 ) reduced superoxide generation
Lin et al., Br J Pharmacol 1998 : 9. We conclude that UTP induced cPLA2 activity depends on the activation of PI-PLC and the sustained elevation of intracellular Ca2+, which is essential for the activation of cPLA2 by UTP and thapsigargin