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CCK — HDC

Text-mined interactions from Literome

Kölby et al., Regul Pept 1999 (Carcinoid Tumor...) : Thus CCK-B/gastrin receptor blockade of hypergastrinemic animals reduces the HDC mRNA expression in normal mucosa but not in ECL cell carcinoids ... These results demonstrate that HDC mRNA expression in neoplastic ECL cells is not controlled by CCK-B/gastrin receptors
Kawabata et al., Regul Pept 1991 : Effect of cholecystokinin receptor antagonists, MK-329 and L-365,260, on cholecystokinin induced acid secretion and histidine decarboxylase activity in the rat ... To elucidate the regulatory mechanism of acid secretion by cholecystokinin (CCK) in vivo, we compared the effects of CCK and gastrin on acid secretion and histidine decarboxylase (HDC) activity ... Both CCK and gastrin were potent in increasing fundic HDC activity, and the effect of CCK on HDC activity was significantly inhibited by L-365,260, but not by MK-329
Ding et al., Gastroenterology 1995 : The effects of the dipeptoids and of gastrin-17 and sulfated CCK-8 on rat stomach HDC activity were examined ... The CCK-B receptor antagonist L-365,260 inhibited the HDC activation induced by gastrin, sulfated CCK-8 , or the dipeptoids ... Gastrin, sulfated CCK-8 , and the dipeptoids activated rat stomach HDC
Höcker et al., Am J Physiol 1996 : Gastrin and cholecystokinin (CCK) octapeptide equipotently stimulated the transcriptional activity of the rat HDC promoter three- to fourfold, and deletion analysis revealed the presence of a gastrin response element within 201 nucleotides upstream of the translational start site ... These data indicate that stimulation of the CCK-B/gastrin receptor activates the rat HDC promoter in a time- and dose dependent fashion and that this effect is primarily mediated via a PKC dependent signaling pathway