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Jiang et al., Blood 2000
:
In contrast, cyclin-E and p27 ( KIP1 ) protein levels and cdk2 activity in cells adherent to FN in the presence of IL3 or SCF were similar to those in PLL-adherent and FN-nonadherent or PLL-nonadherent cells
Halfter et al., Cancer Res 2006
(Glioblastoma) :
Degradation of p27 in late G ( 1 ) and S phase is initiated by the ubiquitin ligase complex SCF-Skp2/Cks1 Huss et al., Exp Mol Pathol 1995
:
SCF induces a transient expression of p27kip-1, while no p27kip-1 is detectable in the presence of IL-6 or an anti-SCF monoclonal antibody