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BDNF — HSPG2

Text-mined interactions from Literome

Dijkhuizen et al., J Neurobiol 2005 : BDNF leads to the rapid activation of PI3-kinase, MAP kinase, and PLC-gamma in cortical neurons, and pharmacological inhibition of PI3-kinase and MAP kinase in dissociated cell cultures and cortical slice cultures suppresses the ability of BDNF to induce dendrite formation
Yagasaki et al., J Biol Chem 2006 : We found that the BDNF stimulated PLC-gamma activation and the ensued increase in intracellular Ca2+ ( [ Ca2+ ] i ) were potentiated by pretreatment with imipramine or fluvoxamine, so was the BDNF induced glutamate release ... Interestingly, BD1047, a potent Sig-1R antagonist, blocked the imipramine dependent potentiation on the BDNF induced PLC-gamma activation and glutamate release ... In contrast, overexpression of Sig-1R per se, without antidepressant pretreatment, enhances BDNF induced PLC-gamma activation and glutamate release
Numakawa et al., Proc Natl Acad Sci U S A 2009 : Corticosterone, a natural glucocorticoid, also reduced TrkB-GR interaction, BDNF stimulated PLC-gamma , and BDNF triggered glutamate release ... Interestingly, BDNF dependent binding of PLC-gamma to TrkB was diminished by DEX
Numakawa et al., Neuroscience 2013 : In CNS neurons, BDNF triggers activation of phospholipase C? ( PLC? ) , mitogen activated protein/extracellular signal regulated kinase ( MAPK/ERK ), and phosphoinositide 3-kinase (PI3K)/Akt pathways, influencing neuronal cells beneficially through these intracellular signaling cascades