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AKT3 — CASP2

Text-mined interactions from Literome

Kelley et al., J Biol Chem 1999 : These data suggest that M-CSF may induce cell survival through Akt induced suppression of caspase-9 activation
François et al., J Neurochem 1999 (Neuroblastoma) : The phosphatase inhibitors orthovanadate and okadaic acid prevented catalytic processing and activation of caspase-3 and digestion of Akt and partially inhibited cleavage of caspase-9
Matsuzaki et al., J Neurochem 1999 : Adenovirus mediated overexpression of the activated form of Akt significantly inhibited NO-induced cell death, caspase-3-like activation, and changes in Bcl-2 and Bax expression
Bachelder et al., J Cell Biol 1999 (Colorectal Neoplasms) : The involvement of caspase 3 in AKT/PKB regulation was indicated by the ability of Z-DEVD-FMK, a caspase 3 inhibitor, to block the alpha6beta4 associated reduction in AKT/PKB levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of AKT/PKB in vitro ... In addition, the ability of alpha6beta4 to activate AKT/PKB could be restored in p53 wild-type carcinoma cells by inhibiting caspase 3 activity
Rokudai et al., J Cell Physiol 2000 : These results indicate that caspase dependent cleavage of anti-apoptotic Akt turns off the survival signals, resulting in the acceleration of apoptotic cell death
Mo et al., Biochem Biophys Res Commun 2000 : This decrease of Akt level was not prevented by caspase inhibitors
Tang et al., J Biol Chem 2001 : Akt is cleaved during mitochondrial mediated apoptosis in a caspase dependent manner
Zhang et al., Cell Death Differ 2001 (MAP Kinase Signaling System) : PI3-kinase/Akt signaling attenuated caspase-8 activity, whereas MAP kinase signaling impaired caspase-9 activity
Tomimatsu et al., Neurosci Lett 2001 (Asphyxia Neonatorum...) : To investigate the effect of hypothermia on cell death and cell survival signal pathways, we studied caspase-3-like activity and activation of Akt in a rat model of neonatal hypoxic-ischemic ( H-I ) brain injury
Suhara et al., Mol Cell Biol 2002 : Diminished Akt signaling promoted the cleavage of caspase 3, and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA
Fecteau et al., J Pharmacol Exp Ther 2002 (Cell Transformation, Neoplastic) : Induction of apoptosis of ras transformed cells by FR901228 correlates with suppression of the extracellular signal regulated kinase ( ERK ) signaling pathway through reduction of Raf expression and deactivation of Mek and Erk, inhibition of the phosphoinositide-3 kinase (PI3-K) pathway indexed by suppression of Akt activity, suppression of p38 activity, and activation of caspase-3
Yusta et al., J Biol Chem 2002 : We now demonstrate that GLP-2, in a cycloheximide-insensitive manner, enhanced survival in baby hamster kidney cells stably transfected with the rat GLP-2R ; reduced mitochondrial cytochrome c efflux ; and attenuated the caspase dependent cleavage of Akt , poly ( ADP-ribose ) polymerase, and beta-catenin following inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002
Sun et al., J Invest Dermatol 2002 (Carcinoma, Squamous Cell...) : Ganglioside depletion promotes survival of the human keratinocyte derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin linked kinase, protein kinase B/Akt , and Bad, with resultant inhibition of caspase-9 activation
Golubovskaya et al., J Biol Chem 2002 (Breast Neoplasms) : In low EGFR expressing BT474-pcDNA3 vector control cells, inhibition of FAK by the FAK C-terminal domain caused detachment and apoptosis via pathways involving activation of caspase-3 and -8, cleavage of poly ( ADP-ribose ) polymerase, and caspase-3 dependent degradation of AKT
Choi et al., Int J Oncol 2002 : Bcl-2 overexpression attenuates arsenic trioxide induced apoptosis in U937 cells by inhibition of caspase 3 activity, but not inhibition of Akt
Bild et al., Oncogene 2002 : MEKK1 induced apoptosis is amplified by blocking PI-3 kinase activation and overexpression of AKT blocked both MEKK1 induced apoptosis and caspase activation
Suhara et al., Neurobiol Aging 2003 (Second Messenger Systems) : Constitutive activation of Akt reversed Abeta induced toxicity and stimulated caspase-3 activity, suggesting that inhibition of Akt signaling is functionally significant
Milani et al., J Neurochem 2003 (Neuroblastoma) : Remarkably, caspase dependent cleavage of NF-kappaB family members as well as of Akt and CREB proteins, but not of ERK, became prominent at 24 h, a time point coincident with the peak of caspase dependent apoptosis
Dery et al., Reproductive biology and endocrinology : RB&E 2003 : These results suggest that increased Akt expression and activity in response to estradiol may be an important mechanism to protect endometrial cells from apoptotic triggering and to induce endometrial cell proliferation, whereas inhibition of Akt activity leads to caspase-3 activation and apoptosis in endometrial cells
Wang et al., J Biol Chem 2003 : Inhibition of UV-induced activation of Akt increased release of mitochondrial cytochrome c 3.5-fold, and caused appearance of active forms of caspase-9 , caspase-8, and caspase-3
Yin et al., Hypertension 2004 (Myocardial Reperfusion Injury) : GSK-3 and caspase-3 activities were both blocked by Ad.DN-Akt and lithium, whereas only caspase-3 was inhibited by its inhibitor Z-VAD
Kiessling et al., J Biol Chem 2004 : However, IL-11 stimulation resulted in a dose dependent tyrosine phosphorylation of Akt , a decreased activation of caspase-9 , and a reduced induction of apoptosis in cultured CEC
Tohyama et al., Curr Pharm Des 2004 (Fanconi Anemia...) : Syk might inhibit the activation of caspase-9 through Akt thereby protecting cells from oxidative stress induced apoptosis
Lee et al., Clin Cancer Res 2004 (Breast Neoplasms...) : Our results suggest that caspase-3 is involved in the reduction of Akt level, and its involvement is mediated through caspase-9 activation
Pan et al., Mol Biol Cell 2004 : Here we show that a kinase inactive RSK mutant blocks KGF induced Akt activation and KGF mediated inhibition of caspase 3 activation in epithelial cells subjected to oxidative stress
Yang et al., Circulation 2004 (Arterial Occlusive Diseases...) : In vivo, celecoxib reduced injury induced phosphorylation of Akt and GSK, reduced VSMC proliferation, and increased caspase-3 activation and VSMC apoptosis at 3 days after injury, whereas aspirin had no effect
Shi et al., J Biol Chem 2004 (Glioma) : Cells expressing SPARC display increased AKT activation with decreased caspase 3/7 activity ... Furthermore, AKT activation is essential for the anti-apoptotic effects of SPARC as the decreased apoptosis and caspase activity associated with SPARC expression can be blocked with dominant negative AKT or a specific AKT inhibitor
Woo et al., Biochem Biophys Res Commun 2004 : Overexpression of a constitutively active Akt ( myr-Akt ) in U937 cells inhibited the induction of apoptosis, activation of caspase 3, and PLC-gamma1 cleavage by chrysin
Yin et al., J Biol Chem 2005 (Anoxia...) : The effect of kallikrein on cardiomyocyte survival was blocked by dominant negative Akt and a constitutively active mutant of GSK-3beta, but it was facilitated by constitutively active Akt , catalytically inactive GSK-3beta, lithium, and caspase-3 inhibitor ... Moreover, kallikrein promoted Bad.14-3-3 complex formation and inhibited Akt-GSK-3beta dependent activation of caspase-3 , whereas caspase-3 administration caused reduction of the Bad.14-3-3 complex, indicating an interaction between Akt-GSK-caspase-3 and Akt-Bad.14-3-3 signaling pathways
Koh et al., Brain Res Mol Brain Res 2005 : To evaluate the protective effects of low concentration of DADS on oxidative stress injured nPC12 cells, the viability of the cells ( pretreated with DADS for 2 h vs. not pretreated ) was evaluated 24 h after exposure to 100 microM H2O2 for 30 min. Compared to the cells treated with 100 microM H2O2 only, pretreatment of the cells with 20 microM DADS before exposure to 100 microM H2O2 increased the viability and induced activation of PI3K and Akt , inactivation of GSK-3, and inhibition of cytochrome c release, caspase-3 activation , and PARP cleavage ... These results indicate that low concentration of DADS has neuroprotective effects by activating PI3K/Akt and by inhibiting GSK-3 activation, cytochrome c release, caspase-3 activation, and PARP cleavage, whereas high concentration is rather cytotoxic
Puduvalli et al., Apoptosis 2005 (Glioma) : Conversely, TRAIL induced caspase dependent cleavage of Akt neutralizing its anti-apoptotic effects
Stanic et al., J Cell Physiol 2006 : DFMO also reduced the increase in caspase activity induced by staurosporine, but in this case Akt inhibition prevented the DFMO effect
Rokhlin et al., Oncogene 2005 : There is a direct, androgen dependent correlation between the levels of activated Akt and caspase activation after treatment with TNF-alpha and TRAIL
Gao et al., Blood 2006 (Leukemia) : Enforced activation of Akt blocked 2-ME/HDACI mediated mitochondrial injury, caspase activation, and JNK up-regulation, but not generation of ROSs
Liu et al., Mol Cancer Ther 2006 (Breast Neoplasms) : Interestingly, the nonspecific caspase inhibitor, z-VAD-FMK, inhibited the down-regulation of Akt , XIAP, and cIAP-1 in cerulenin- and LY294002 treated cells
Zhuang et al., American journal of physiology. Renal physiology 2007 : ERK promotes hydrogen peroxide induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
Colleselli et al., Exp Cell Res 2006 : Further analyses revealed an implication of Akt phosphorylation and caspase-3 activation
Zhang et al., Neuroscience 2006 (Disease Models, Animal...) : Akt activation results in decreased serine phosphorylation of 14-3-3, a cytoplasmic anchor of Bax, and prevents ischemia induced mitochondrial translocation of Bax, release of cytochrome c, and activation of caspase-3
Xu et al., Atherosclerosis 2007 : Inhibitors of the Akt , ERK1/2, Src kinase and transfection with a dominant negative Akt cDNA blocked the inhibitory effect of cyanidin on cleaved caspase-3
Granado-Serrano et al., J Nutr 2006 (Carcinoma, Hepatocellular...) : Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line ( HepG2 )
Charalambous et al., Carcinogenesis 2007 (Neoplasms) : This is accompanied by down-regulation of Akt and activation of caspase-3 and p38 mitogen activated protein kinase ( MAPK )
Huang et al., J Cell Biochem 2007 (Necrosis...) : These data suggest that magnolol promoted apoptosis probably by alleviating the inhibitory effect of Akt on caspase 9
Zeuner et al., Cancer Res 2007 (Thrombocytopenia) : In chemotherapy treated megakaryocytes, SCF activated Akt , neutralized the mitochondrial apoptotic machinery, and inhibited caspase activity
Xue et al., Biochem Biophys Res Commun 2007 (Reperfusion Injury) : In contrast, MF-1 treatment up-regulated Akt phosphorylation, and inhibited caspase 3 activation and tubular apoptosis, thereby ameliorating renal dysfunction
Camacho-Leal et al., Oncogene 2008 (MAP Kinase Signaling System) : The CEA mediated caspase inactivation as well as activation of Akt was not observed by expression of a CEA molecule incapable of self binding ( DeltaNCEA )
Guo et al., Circ Res 2007 : The Mfn-2 proapoptotic effect is independent of its role in mitochondrial fusion but mainly mediated by inhibition of Akt signaling and the resultant activation of the mitochondrial apoptotic pathway, as manifested by decreased Akt phosphorylation, increased mitochondrial Bax/Bcl-2 ratio, cytochrome c release, and activation of caspases-9 and caspase-3
Baki et al., J Neurosci 2008 (Alzheimer Disease...) : Familial Alzheimer disease ( FAD ) mutations suppress the ability of PS1 to promote PI3K/AKT signaling, prevent phosphorylation/inactivation of GSK-3 and promote activation of caspase-3
Ishigami et al., Br J Cancer 2008 (Carcinoma, Squamous Cell...) : Downregulation of ICAM2 expression by siRNA enhanced radiosensitivity of OSCC cells with the increased apoptotic phenotype via phosphorylation ( ser473 ) of AKT and activation of caspase-3
Starvaggi Cucuzza et al., Phytomedicine 2008 : This effect may be modulated by MAPK and Akt activation that Echinacea extract treatment increased and/or by a reduction of caspase 3 activity, showed a dose-response decrease after Echinacea treatment
Jane et al., Cancer Lett 2008 (Glioma) : Simultaneous exposure to both agents significantly increased the release of cytochrome c, as well as caspase 3 activation, Bax cleavage, and inhibition of Akt phosphorylation
O'Donnell et al., In Vitro Cell Dev Biol Anim 2008 (Ovarian Neoplasms) : BRAt also reduced levels of phosphorylated Akt and overexpression of activated Akt in BRAt cells restored caspase-3 activity to that seen in wild-type cells
Park et al., Food Chem Toxicol 2008 (Leukemia) : Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells
Oh et al., Apoptosis 2008 (Leukemia) : Furthermore, we have shown that overexpression of Bcl-2 and active Akt ( myr-Akt ) in U937 cells inhibited the induction of apoptosis, activation of caspase-3 , and PLC-gamma1 cleavage by withaferin A. Taken together, our results indicated that the JNK and Akt pathways and inhibition of NF-kappaB activity were key regulators of apoptosis in response to withaferin A in human leukemia U937 cells
Palozza et al., J Nutr Biochem 2010 : Concomitantly, it inhibited 7-KC induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT , Bcl-2, Bcl-xL and Bax
Starvaggi Cucuzza et al., J Anim Physiol Anim Nutr (Berl) 2010 : These effects may be related with protein kinase B ( AKT ) activation induced by silymarin treatment ( p < 0.05 ) and/or by a dose related inhibitory effect ( p < 0.05 ) on caspase-3 activity related to a protective role in cell apoptosis
Rafei et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : Treatment of CD4 T cells derived from experimental autoimmune encephalomyelitis mice with GMME1 leads to p38 hyperphosphorylation, inhibition of p44/42, AKT and STAT3 phosphorylation, and caspase-3 activation
Kang et al., Wound Repair Regen 2009 (Disease Models, Animal...) : The proliferation of cells exposed to gamma-irradiation is also stimulated by exposure to SP, a phenomenon that may result from inhibition of apoptosis because SP activates Akt and inhibits the cleavage of caspase-3
Lee et al., Clin Cancer Res 2009 (Mammary Neoplasms, Experimental) : Mixed tocopherols increased the expression of p21, p27, caspase-3 , and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors
McCleese et al., Int J Cancer 2009 (Bone Neoplasms...) : Finally, STA-1474 induced tumor regression, caspase-3 activation and downregulation of p-Met/Met and p-Akt/Akt in OSA xenografts
Montecucco et al., J Biomed Biotechnol 2009 (Inflammation) : Oxaprozin pro-apoptotic activity was associated with the inhibition of CD40L triggered Akt and NF-kappaB phosphorylation and the activation of caspase 3
Kim et al., Proc Natl Acad Sci U S A 2009 : OPN D135A/D157A sustains AKT activity to increase cell viability through inhibition of caspase-9 during Hyp/RO
Lee et al., Cancer Res 2009 (Ovarian Neoplasms) : Pharmacologic inhibition of Akt with LY294002 abrogated insulin- or serum induced eEF1A2 expression and increased the caspase-3 activity
Fuentealba et al., J Biol Chem 2009 (Neurodegenerative Diseases) : A correlation between decreased Akt phosphorylation and the activation of caspase-3 was demonstrated in LRP1 knocked down neurons
Gatson et al., Journal of neuroinflammation 2009 (Burns...) : In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Seo et al., J Neurochem 2010 (Anoxia...) : The results indicate that hypoxia protects neuronal cells against PrP ( 106-126 ) -induced cell death by activating the Akt signal, which is inactivated by prion proteins, and inhibiting PrP ( 106-126 ) -induced caspase 3 activation
Kim et al., Int J Oncol 2010 (Adenocarcinoma...) : We also found that during OGD induced apoptosis the prosurvival protein kinase Akt is activated and inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitors LY294002 and wortmannin prevent OGD induced apoptosis, caspase-3 and -9 activation, and nuclear translocation of AIF and EndoG
Cheng et al., Vascul Pharmacol 2010 (Disease Models, Animal...) : Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage
Choi et al., Anticancer Res 2009 (Adenocarcinoma...) : Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL mediated apoptosis via down-regulation of AKT and activation of caspase-3
Wu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 : Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA
Inamura et al., J Anesth 2010 (Reperfusion Injury) : This caspase activation is mediated by phosphorylation of Akt and ERK
Liao et al., American journal of translational research 2010 : Reports on ubiquitin dependent Akt degradation, caspase dependent cleavage, and the roles of molecular chaperone heat shock protein 90 (Hsp90) in the regulation of Akt stability are summarized
Lokeshwar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : 4-MU induced caspase-8, caspase-9 , and caspase-3 activation, PARP cleavage, upregulation of Fas-L, Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated Akt , phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor
Lane et al., Oncogene 2010 (Ascites...) : The ability of ovarian cancer ascites to activate Akt and inhibit TRAIL induced cell death and caspase activity was decreased by heat inactivation, but was retained in ascites fractions > 5 kDa
Liu et al., Ann Hematol 2010 (Leukemia, Myeloid) : Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro
Scherbik et al., J Virol 2010 (MAP Kinase Signaling System...) : Reduction of Ca ( 2+ ) influx at early times of infection by various treatments decreased the viral yield and delayed both the early transient caspase 3 cleavage and the activation of FAK, Akt , and ERK signaling
Dedoni et al., J Neurochem 2010 (Neuroblastoma) : Similarly, in mouse primary neurons IFN-ß induced STAT phosphorylation, caspase 3 cleavage and inhibition of Akt signaling
Sun et al., Int J Oncol 2011 : TRAIL induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt
Jabbour et al., Transplantation 2011 (Myocardial Reperfusion Injury) : Functional improvements were accompanied by increased phosphorylation of Akt , ERK1/2, STAT3, and GSK-3ß and reduced cleaved caspase-3 ( P < 0.01 )
Xiang et al., Cell Biochem Funct 2011 : The inhibitory effect of ghrelin on caspase-3 activity was attenuated by inhibitors of ERK1/2 ( PD98059 ), PI3K/Akt ( LY294002 ) and growth hormone secretagogue receptor ( GHSR ) -1a ( D-Lys ( 3 ) -growth hormone releasing peptide-6 )
Li et al., J Biol Chem 2011 (Lung Neoplasms) : Our previous studies have revealed that acquired tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) resistance in lung cancer cells is associated with Akt mediated stabilization of cellular caspase 8 and Fas associated death domain (FADD)-like apoptosis regulator-like inhibitory protein ( c-FLIP ) and myeloid cell leukemia 1 (Mcl-1)
Yuan et al., PloS one 2011 (Ovarian Neoplasms) : Our findings suggest that BIM plays an important role in regulating p-AKT by activating caspase-3 and that BIM mediates the level of AKT phosphorylation to determine the threshold for overcoming cisplatin resistance in ovarian cancer cells
Liu et al., Int J Biochem Cell Biol 2011 (Breast Neoplasms) : Taken together, our data indicate that Akt/ERK mediated caspase-8 activation and Fas/FasL mediated caspase-8 activation mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells, respectively
Su et al., Am J Physiol Heart Circ Physiol 2012 : Activation of caspase 3 was suppressed in the cardiomyocytes transduced with mitochondria targeted active Akt, whereas a mitochondria targeted dominant negative Akt enhanced activation of caspase 3
Chen et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (Parkinson Disease) : The pharmacological activity of this compound has been studied, and it is associated with the inhibition of 6-OHDA induced activation of caspase-3 and translocation of nuclear factor kappa B. 11-Dehydrosinulariolide increased the activation of survival signaling phospho-Akt but not phospho-ERK
Cai et al., Diabetes 2012 (Glucose Intolerance...) : Reduced ß-cell viability and proliferation resulting in decreased ß-cell mass was observed in these mice, which was associated with attenuated insulin/Akt ( also known as protein kinase B ) and extracellular signal related kinase 1/2 signaling and increased caspase 3 activation
Lee et al., Apoptosis 2012 (Melanoma) : Our data reveal that celastrol inhibits growth and induces apoptosis in melanoma cells via the activation of ROS mediated caspase dependent and -independent pathways and the suppression of PI3K/AKT signaling
Wang et al., Cancer Res 2013 : CF31 inhibition of TNF-a activation of AKT also results in TNF-a dependent activation of caspase-8 and apoptosis
Jin et al., Cell Transplant 2013 : Inhibition of Akt activation in endothelial cells and myocytes by the sensitive and specific antagonist API-1 during 24 h of hypoxia nearly completely prevented the beneficial effects of HUCM on inhibiting caspase-3 activity and apoptosis
Ragot et al., Biochem Pharmacol 2013 : To this end, 158N murine oligodendrocytes were treated with 7KC or 7ßOHC inducing an apoptotic mode of cell death characterized by condensation/fragmentation of the nuclei, dephosphorylation of Akt and GSK3, mitochondrial depolarization involving Mcl-1, and caspase-3 activation
Hollborn et al., PloS one 2013 : The cytotoxic effect of curcumin involved activation of caspase-3 and calpain, intracellular calcium signaling, mitochondrial permeability, oxidative stress, increased phosphorylation of p38 MAPK and decreased phosphorylation of Akt protein