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CISH — IL12A
Text-mined interactions from Literome
Yu et al., J Immunol 2004
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We further show that STAT1 signals play major roles in inducing SOCS expression in Th cells and that
induction of
SOCS expression by IL-4,
IL-12 , or IFN-gamma is compromised in STAT1-deficient primary Th cells
Kozma et al., J Immunol 2006
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PIBF activated
suppressor of cytokine signaling-3 and
inhibited IL-12 induced suppressor of cytokine signaling-1 activation
Dawson et al., BMC immunology 2006
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Stimulation of human PBMCs and purified T cells with ATRA and
9-cis-RA increased mRNA and protein levels of IL-4, IL-5, and IL-13 and decreased levels of IFN-gamma, IL-2,
IL-12p70 and TNF-alpha upon activation with anti-CD3 and/or anti-CD28 mAbs
Carow et al., PLoS Pathog 2013
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Instead,
SOCS3 expression in infected macrophages and DCs
prevented the IL-6 mediated inhibition of TNF and
IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo