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CREB5 — GIP

Text-mined interactions from Literome

Kim et al., J Lipid Res 2010 : GIP in the presence of insulin increased LPL gene expression in human adipocytes and LPL promoter activity in GIP receptor expressing HEK-293 cells, and both effects were greatly reduced by the transcription inhibitor actinomycin D. Subsequent studies established that GIP increased phosphorylation of Serine 133 in cAMP-response element binding protein ( CREB ) and the nuclear localization of cAMP-responsive CREB coactivator 2 ( TORC2 ) through a pathway involving phosphatidylinositol 3-kinase (PI3-K), PKB, and AMP activated protein kinase (AMPK) ... GIP induced phospho-CREB and TORC2 were shown to bind to a cAMP-response element ( -II ) site in the human LPL promoter and GIP increased protein-protein interactions of these two factors
Mohammad et al., J Biol Chem 2011 (Insulin Resistance) : Using pharmacologic and molecular genetic approaches, we show that the effect of GIP on adipocyte insulin sensitivity requires activation of both the cAMP/protein kinase A/CREB signaling module and p110ß phosphoinositol-3 ' kinase, establishing a novel signal transduction pathway modulating insulin action in adipocytes