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APOA2 — LCAT
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tailleux et al., Atherosclerosis 2002
(Arteriosclerosis...) :
Furthermore, the effects of apo A-II on HDL metabolism, beyond cellular cholesterol efflux, are also complex and controversial :
apo A-II may
inhibit lecithin-cholesterol acyltransferase ( LCAT ) ( potential deleterious effect ) and cholesteryl-ester-transfer protein ( CETP ) ( potential beneficial effect ) activities, but may increase the hepatic lipase (HL) activity ( potential beneficial effect )
Chen et al., Eur J Biochem 1986
:
Stimulation of
lecithin:cholesterol acyltransferase activity by
apolipoprotein A-II in the presence of apolipoprotein A-I ... Various combinations of incorporation and addition of apolipoprotein A-I (apo A-I) and apolipoprotein A-II (apo A-II) individually or together to a defined lecithin-cholesterol ( 250/12.5 molar ratio ) liposome prepared by the cholate dialysis procedure were used to study the
effect of
apo A-II on
lecithin:cholesterol acyltransferase ( LCAT, EC 2.3.1.43 ) activity of both purified enzyme preparations and plasma ... However, when the same amounts ( 0.1-3.0 nmol/assay ) of apo A-II were incorporated together with apo A-I ( 0.8 nmol/assay ) into the liposome,
apo A-II significantly
stimulated LCAT activity as compared to activity obtained with incorporation of apo A-I alone ... These results indicated that apo A-II must be incorporated together with apo A-I into lecithin-cholesterol liposomes to exert its stimulatory effect on LCAT activity and that
apo A-II in high-density lipoprotein may
play an important role in the regulation of
LCAT activity