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BMP2 — PI3

Text-mined interactions from Literome

Ghosh-Choudhury et al., J Biol Chem 2003 : BMP-2 increased PI 3-kinase activity in these cells in a time dependent manner, resulting in increased expression of sarcomeric myosin heavy chain ( MHC ) and MEF-2A ... BMP-2 also increased transcription of a reporter gene driven by an MEF-2-specific DNA element in a PI 3-kinase dependent manner ... Together these data provide the first evidence that BMP-2 induced PI 3-kinase signaling regulates MEF-2A expression and define a mechanism of MEF-2A dependent BMP-2 transcription
Ghosh-Choudhury et al., FEBS Lett 2003 : Ly294002, a pharmacological inhibitor of PI 3 kinase, blocked BMP-2 induced PI 3 kinase activity completely ... Also we provide the first evidence that BMP-2 induced PI 3 kinase activity regulates this cardiomyocyte function
Sugimori et al., J Bone Miner Metab 2005 : We investigated the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt mediated NF-kappaB activation by BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511
Gamell et al., J Cell Sci 2008 : BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity
Graham et al., Cancer Sci 2010 (Neoplasm Metastasis...) : We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt ) mediates transcriptional regulation and activation of bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-kappaB in bone metastatic prostate cancer cells
Liu et al., Biochem Biophys Res Commun 2013 : Furthermore, in the presence of exogenous BMP-2 , PI3K and Akt inhibitors blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ghosh-Choudhury et al., J Biol Chem 2013 : Remarkably, inhibition of c-Abl significantly suppressed BMP-2 stimulated PI 3-kinase activity and its downstream Akt phosphorylation