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EPHB2 — PDGFB

Text-mined interactions from Literome

Rönnstrand et al., Oncogene 1999 : Moreover, PDGF-BB induced Ras GTP loading and Erk2 activation were severely compromised in the receptor mutant
Cospedal et al., Biochem J 1999 : TGF-beta(1) had no inhibitory effect on ERK activation induced by PDGF-BB or bFGF
Sachinidis et al., Br J Pharmacol 2000 : Furthermore CTX attenuated the PDGF-BB induced tyrosine phosphorylation of the PDGF-Rbeta, PI 3'-K, PLC-gamma1 and ERK1/2 indicating an action of cyclic AMP on PDGF-beta receptor
El Mabrouk et al., Life Sci 2000 : ERK1/2 phosphorylation induced by PDGF-BB and FBS was not affected by pre-treatment with L-NAME or aminoguanidine
Hauck et al., J Biol Chem 2000 : As demonstrated using FAK-deficient and FAK reconstituted fibroblasts, FAK positively contributed to PDGF-BB stimulated ERK2/MAP kinase activity, and in SMCs, ERK2/MAP kinase activity was required for PDGF-BB stimulated chemotaxis
Chaudhary et al., J Cell Biochem 2001 : The results demonstrated that both ERK1 and ERK2 were activated by FGF-2 and PDGF-BB ... Activation of ERK1 and ERK2 by PDGF-BB and FGF-2 was inhibited by PD 098059 ( 100 microM ), a specific inhibitor of MEK ... Taken together, our data for the first time revealed that the activation of ERK1/2 by PDGF-BB is mediated by PI 3-K, and secondly, Akt is activated by PDGF-BB and EGF but not by FGF-2 in human and mouse osteoblastic cells
Daum et al., Mol Cell Biochem 2001 : Unexpectedly, in V12Ras expressing-SMCs, arsenite stimulates ERK, but still decreases ERK activity in the presence of PDGF-BB
Oak et al., Mol Pharmacol 2001 : The Src-family tyrosine kinase inhibitor PP2 blocked MAPK activation by dopamine ; however, this drug was also found to inhibit PDGF-BB stimulated ERK activity and autophosphorylation of the PDGF receptor-beta
Patel et al., Thromb Haemost 2002 (MAP Kinase Signaling System) : In parallel studies, fucoidan, but not heparin, inhibited ERK1/ERK2 activation by PDGF-BB
Tangkijvanich et al., J Cell Physiol 2002 : PDGF-BB also induced activation of p38 MAP kinase, its downstream effector, heat shock protein (HSP) 27, ERK 1 and ERK 2, and p125 focal adhesion kinase (FAK) ... Selective antagonism of ERK kinase inhibited PDGF-BB induced ERK phosphorylation and proliferation, but did not affect PDGF-BB stimulated migration
Cellier et al., Can J Physiol Pharmacol 2002 : We observed that the activation of B2R negatively modulates the phosphorylation of Erk1 and Erk2 induced by IGF-1, PDGF-BB , and HG in the glomerulus
Masamune et al., Tohoku J Exp Med 2003 (Fibrosis) : Activation of PI 3-kinase was not required for PDGF-BB induced ERK activation
Kamiyama et al., J Atheroscler Thromb 2003 (Arteriosclerosis) : Cerivastatin and GGTI-286, but not FTI-277, suppressed the PDGF-BB induced activation of extracellular signal related kinase ( ERK1/2 ) ... The inhibitory effect of cerivastatin on the PDGF-BB induced activation of ERK1/2 was fully recovered by the addition of geranylgeranyl pyrophosphate ( GGPP ), but not farnesyl pyrophosphate ( FPP ) ... These data indicate that the PDGF-BB induced activation of ERK1/2 and proliferation of VSMCs depend upon geranylgeranylated small G protein ... Furthermore, Y-27632 suppressed the PDGF-BB induced activation of ERK1/2 and proliferation of VSMCs
Sundberg et al., J Biol Chem 2003 : However, FRNK expression did not alter the magnitude or dynamics of ERK activation induced by PDGF-BB or angiotensin II
Sarjeant et al., Arterioscler Thromb Vasc Biol 2003 (Arteriosclerosis) : ApoD did not suppress PDGF-BB or fibroblast growth factor-2 induced phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 but selectively inhibited PDGF-BB mediated ERK1/2 nuclear translocation
Kagami et al., J Cell Physiol 2004 (Glomerulonephritis) : PDGF-BB enhanced not only gel contraction but ERK phosphorylation and AP-1 activity by MCs ... Marked inhibitory effects on PDGF-BB induced gel contraction and ERK/AP-1 activity were observed in the presence of either function blocking anti-alpha1- or anti-beta1-integrin antibody or U0126
Sanz-González et al., Biochem Biophys Res Commun 2004 : We also found that STI571 abrogates PDGF-BB dependent activation of extracellular regulated kinase 1 and 2 ( ERK1/2 ), and forced activation of these factors impaired STI571 dependent inhibition of both cyclin A promoter activity and SMC proliferation
Gao et al., J Biol Chem 2005 (Wounds and Injuries) : Concerning the PDGF signaling, PDGF-BB induced phosphorylation of Akt, ERK1/2 , and JNK, but not p38, decreased in PDGFR-betaDelta/Delta fibroblasts, but PDGF-AA induced signaling was not altered ... Overexpression of the phospholipid phosphatases, SHIP2 and/or PTEN, inhibited PDGF-BB induced phosphorylation of Akt and ERK1/2 in PDGFR-betaDelta/Delta fibroblasts but did not affect that of JNK and p38 ... These results indicate that disruption of distinct PDGFR-beta signaling pathways in PDGFR-betaDelta/Delta dermal fibroblasts impaired their proliferation and survival, but completely inhibits migratory response, and that PDGF-BB induced phosphorylation of Akt and ERK1/2 possibly mediated by PDGFR-alpha is regulated, at least in part, by the lipid phosphatases SHIP2 and/or PTEN
Millette et al., Circ Res 2005 : In the presence of bFGF antibody, PDGF-BB induced early activation of ERK ( 0 to 60 minutes ) was not affected, whereas late ERK activation ( 2 to 4 hours ) was reduced
Takayama et al., J Biol Chem 2005 : This was accompanied by rapid uptake of receptor bound PDGF-BB into the cells and by attenuated ERK activation in response to PDGF-BB stimulation
Dardik et al., J Vasc Surg 2005 : Inhibition of PDGF-BB or IL-1alpha inhibited SMC chemotaxis and ERK1/2 phosphorylation
Yuantai et al., Indian J Gastroenterol 2005 : Expression of p ERK1 protein was up-regulated by PDGF-BB , and was down-regulated in a dose dependent manner by PD98059
Romano et al., J Cell Physiol 2006 : PI3K, ERK , JNK, and p38 kinases, known to mediate PDGF-BB signaling in the canonic dedifferentiative and proliferative response of smooth muscle cells ( SMC ) were rapidly activated by PDGF-BB but only p38 remained activated after 2-day stimulation
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited PDGF-BB induced cyclin D1 expression and activation of extracellular signal regulated kinase ( ERK )
Jeon et al., J Cell Biochem 2007 : SPC treatment induced sustained activation of an extracellular signal regulated kinase ( ERK ), in contrast to transient activation of ERK in response to platelet derived growth factor (PDGF)-BB , which stimulated proliferation of MS1 cells
Lo et al., Biochem Pharmacol 2007 : We found that preincubation of PDGF-BB with lycopene resulted in a marked inhibition on PDGF-BB induced PDGF receptor-beta ( PDGFR-beta ), PLCgamma, and ERK1/2 phosphorylation in rat A10 SMCs and primary cultured aortic SMCs
Rovida et al., J Hepatol 2008 : PDGF-BB rapidly induced ERK5 activation and translocation to the nucleus ... Interfering with Src activation blocked PDGF-BB dependent ERK5 phosphorylation
Wu et al., Pharmacol Res 2009 (MAP Kinase Signaling System) : FBS- and PDGF-BB stimulated intracellular Ras, MEK1/2, ERK1/2 , proliferative cell nuclear antigen ( PCNA ), and Akt activations were significantly inhibited by lercanidipine ; however, lercanidipine did not affect FBS- and PDGF-BB induced STAT3 phosphorylation
Chen et al., J Biol Chem 2009 : Knockdown of FRS2 in VSMC by RNA interference inhibited PDGF-BB mediated down-regulation of SMA and SM22alpha without affecting PDGF-BB mediated cell proliferation or ERK activation
Abouantoun et al., Mol Cancer Ther 2009 (Medulloblastoma...) : Imatinib ( 1 µmol/L ) treatment of DAOY and D556 cells inhibited PDGF-BB- and serum mediated migration and invasion at 24 and 48 h, respectively, and concomitantly inhibited PDGF-BB activation of PDGFRB, Akt, and ERK but increased PTEN expression and activity
Zheng et al., J Biol Chem 2009 : Of particular interest, Klf4 inhibits RAR alpha and PDGFR beta expression while blocking PI3K and ERK signaling induced by Am80 and PDGF-BB , respectively
Gill et al., Cell Signal 2010 : Downregulation of maturely glycosylated PDGFRbeta by prolonged exposure to PDGF-BB eliminated PDGF-BB mediated ERK1/2 activation
Takami et al., Hepatology research : the official journal of the Japan Society of Hepatology 2010 : Western blot analysis showed that BB-PAC completely or partially inhibited PDGF-BB induced ERK and Akt phosphorylation, respectively
Lennartsson et al., Cell Signal 2010 : In the present study, we found that stimulation with platelet derived growth factor (PDGF)-BB leads to a transient activation of Erk5 , which was shown to be dependent on recruitment of both Src kinases and the tyrosine phosphatase Shp2 to the activated PDGF receptor beta ( PDGFRbeta )
Tomkowicz et al., Cancer Biol Ther 2010 : However, when TEM-1 expression was knocked-down, PDGF-BB induced proliferation, ERK-1/2 phosphorylation, and c-Fos expression were significantly impaired
Yuan et al., Clin Exp Metastasis 2010 (Brain Neoplasms...) : Herein we demonstrate that PDGF-BB treatment of MB cells induces concomitant activation of PDGFRß, MEK1/ERK , Rac1 and Pak1, but suppresses Rho activity, which together significantly promotes cell migration
Seidel et al., Respir Res 2010 (Airway Remodeling) : PDGF-BB induced the phosphorylation of ERK1/2 and p38 MAPK, but not of JNK
Xu et al., Clin Exp Pharmacol Physiol 2011 : In addition, TSG suppressed PDGF-BB induced downregulation of p27 and upregulation of p21, as well as PDGF-BB induced activation of ERK1/2
Bethel-Brown et al., J Immunol 2011 : Furthermore, PDGF-BB induction was regulated by activation of ERK1/2 and JNK signaling pathways and the downstream transcription factor early growth response 1
Weakley et al., J Surg Res 2011 (Disease Models, Animal...) : PDGF-BB substantially induced ERK1/2 phosphorylation in GNP control cells ; this PDGE-BB induced ERK1/2 phosphorylation was significantly inhibited in GA-GNP treated cells compared with GNP only
Choi et al., Environ Toxicol Pharmacol 2011 : Additionally, AF inhibited PDGF-BB induced Akt and ERK1/2 phosphorylation
Yao et al., J Neurosci 2012 : Blocking TRPC1 channel suppressed PDGF mediated proliferation as well as PDGF-BB induced ERK/CREB and mTOR/4E-BP-p70S6K activation, thereby underscoring its role in this process
Uemura et al., FASEB J 2013 : Treatment of VSMCs with CTRP9 protein attenuated the proliferative and chemotactic activities induced by growth factors including platelet derived growth factor (PDGF)-BB, and suppressed PDGF-BB stimulated phosphorylation of ERK ... CTRP9 treatment dose-dependently increased cAMP levels in VSMCs. Blockade of cAMP-PKA pathway reversed the inhibitory effect of CTRP9 on DNA synthesis and ERK phosphorylation in response to PDGF-BB
Peng et al., Eur J Clin Invest 2013 (Liver Cirrhosis...) : AKF-PD treatment attenuated PDGF-BB induced upregulation of phosphorylation of ERK1/2 , p38 and JNK
Kesavan et al., PloS one 2013 : Furthermore, PDGF-BB induced ERK1/2 activation and consequent increase in cellular nitric oxide ( NO ) levels were also blocked by the extract
Chaudhary et al., Biochem Biophys Res Commun 1997 : Activation of extracellular signal regulated kinases 1 and 2 ( ERK1 and ERK2 ) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells : differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells ... Results have demonstrated that in addition to ERK2, ERK1 is activated by FGF-2 and PDGF-BB in normal HOB and HBMS cells
Chaudhary et al., Mol Cell Biochem 1998 : Mainly ERK2 was rapidly activated ( within 10 min ) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106 ... Furthermore, ERK2 was also activated by bFGF and PDGF-BB in the mouse osteoblastic cell line, MC3T3-E1
Pukac et al., Exp Cell Res 1998 : Western analysis confirmed that ERK was strongly activated by PDGF-BB and PMA but not by IGF-I