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PIAS4 — TCF7L2

Text-mined interactions from Literome

Yamamoto et al., EMBO J 2003 : Although PIASy did not affect the interaction of Tcf-4 with beta-catenin or DNA, Tcf-4, SUMO-1 and PIASy were co-localized in the nucleus and present in a complex in the PML body ... PIASy enhanced beta-catenin dependent transcriptional activity of Tcf-4 , whereas Axam inhibited it ... Furthermore, beta-catenin and PIASy activated Tcf-4 ( K297R ), in which Lys297 was changed to arginine, less than wild-type Tcf-4
Ihara et al., Mol Cell Biol 2005 : These results suggest that sumoylation of Lys ( 35 ) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy dependent sumoylation and transcriptional activation of Tcf-4